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Tissue hydration of malignant and uninvolved human tissues and its relevance to proton spin-lattice relaxation mechanism

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Proceedings / Indian Academy of Sciences

Abstract

With a view to investigating the role of the water content in spinlattice relaxation mechanism of water protons, we have measured the water content and T1 in more than one hundred sets of malignant (involved) and uninvolved human biopsies. The involved breast tissues have longer T1 as well as higher water content than those of the corresponding uninvolved tissues. In gastro-intestinal tumours the water content of the uninvolved tissue in general is not much different from that of the involved tissue although the latter have longer T1 values. A similar trend has also been observed in oral tumours. An overall comparison of the data reveals that while the increase in water content is partly responsible for the longer relaxation times in malignant tissues, there is no correlation between the T1 and water content. These results show that other mechanisms apart from the increased water content have also to be considered.

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Authors and Affiliations

  1. Tata Institute of Fundamental Research, 400005, Bombay

    S. R. Kasturi

  2. Cancer Research Institute, 400012, Bombay

    S. S. Ranade & Smita S. Shah

Authors
  1. S. R. Kasturi
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  2. S. S. Ranade
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  3. Smita S. Shah
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Kasturi, S.R., Ranade, S.S. & Shah, S.S. Tissue hydration of malignant and uninvolved human tissues and its relevance to proton spin-lattice relaxation mechanism. Proc. Indian Acad. Sci. 84, 60–74 (1976). https://doi.org/10.1007/BF03045583

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  • DOI: https://doi.org/10.1007/BF03045583

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