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Pathogenese der rheumatoiden Arthritis

Pathogenesis of rheumatoid arthritis

  • Hypothese
  • Published:
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Zusammenfassung

□ Hintergrund

Trotz des Einsatzes moderner molekularer Untersuchungsmethoden ist die Pathogenese von Autoimmunerkrankungen wie der rheumatoiden Arthritis nach wie vor nicht komplett verstanden.

□ Hypothesen

In der vorliegenden Übersichtsarbeit werden die zwei favorisierten Hypothesen zur Pathogenese der rheumatoiden Arthritis vorgestellt und verglichen. Hypothese 1 stellt T-Lymphozyten und T-Lymphozyten-abhängige Phänomene in das Zentrum des pathogenetischen Geschehens. In Hypothese 2 hingegen wird die Rolle alterierter synovialer Fibroblasten und ihrer spezifischen Eigenschaften als kritisch für die Zerstörung entzündetr Gelenke betont. Beide Hypothesen werden sorgfältig diskutiert und Ausblicke für zukünftige Forschungsschwerpunkte gegeben.

□ Schlußfolgerung

Einblicke in die Pathogenese der RA eröffnen Möglichkeiten, neue, auf die Inhibierung pathogenetisch relevanter Prozesse gerichtete Therapieprinzipien zu entwickeln.

Summary

□ Background

Despite ongoing intensive research using sophisticated new molecular tools and methods, the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA) is still not completely understood.

□ Hypotheses

In this paper the two favorite hypotheses of the pathogenesis of theumatoid arthritis currently discussed are introduced and compared. Hypothesis 1 is focussing on the central role of the T cells and T cell dependent phenomena in the pathogenetic scenario of RA. In contrast, hypothesis 2 stresses the role of altered synovial fibroblasts and their specific features critical for the destruction of inflamed joints. Both hypotheses are thoroughly discussed and suggestions for further research activities are made.

□ Conclusion

Insights in the pathogenesis of RA provide options to develop new therapeutic strategies aimed at the inhibition of pathogenetic relevant processes.

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  1. Medizinische Klinik III, Institut für klinische immunologie und Rheumatologie, Universität Erlangen-Nürnberg, Krankenhausstraße 12, D-91054, Erlangen

    Thomas Geiler, Hanns -Martin Lorenz, Joachim R. Kalden & Bernhard Manger

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  4. Bernhard Manger
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Geiler, T., Lorenz, H.M., Kalden, J.R. et al. Pathogenese der rheumatoiden Arthritis. Med Klin 92, 347–353 (1997). https://doi.org/10.1007/BF03044776

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