Zusammenfassung
Seit Einführung der ICD-Therapie 1980 durch Mirowski et al. war eine Klassifikation der Arrhytmieergebnisse nur durch die Auswertung des Episodenzählers in Verbindung mit Begleitsymptomen möglich. Bei über 50% der Patienten bleiben die Tachykardiepisoden einschließlich der Intervention des ICDs symptomlos. Andererseits werden bei ca. 20–40% der Patienten wegen Fehldetektionen oder nichtanhaltenden Kammertachykardien inadäquate Therapien vom ICD abgegeben. Erst die Entwicklung der dritten Gerätegeneration erbrachte die Möglichkeit der Speicherung intrakardialer Signale. Diese können über die bipolare Spitzenelektrode im rechten Ventrikel (“near field”) oder über die Defibrillatioselektroden (“far field”) abgeleitet werden. Damit ist es möglich, neben der Art der Rhytmusstörung auch Auslösemechanismen und Therapieerfolg zu beurteilen. Kriterien zur Analyse der auslösenden Arrhythmie sind die Frequenz, die Stabilität und die Morphologie der Signale.
Mit Hilfe der gespeicherten Elektrogramme können 92–98% der Arrhythmien eindeutig zugeordnet werden. Die Analyse ist bei Patienten mit Schenkelblock und aberierender Überleitung in 5–10% nicht erfolgreich. Fehldetektionen sind in über 50% der Fälle durch tachykardes Vorhofflimmern verursacht. Andere paroxysmale supraventrikuläre Tachykardien oder Sinustachykardien lösen jeweils in ca. 20% inadäquate Therapieabgaben aus. In ca. 17% der Fälle konnte ein Artefaktsensing, meist als Folge eines Sondendefektes, nachgewiesen werden. Die Differenzierung adäquater und inadäquater Therapieabgaben durch gespeicherte Elektrogramme ermöglicht die Prävention unnötiger Schockabgaben und die frühzeitige Erkennung von Sondendefekten. Die Entwicklung von Mehr-Kammer-Systemen mit größerer Speicherkapazität und verbesserten Detektionsalgorithmen kann die Zahl inadäquater Therapieabgaben durch den ICD weiter reduzieren.
Summary
The introduction of implantable cardioverter defibrillators in 1980 by Mirowski et al, offered a new therapeutic device for the treatment of ventrikular tachyarrhythmias. In the beginning it was only possible to evaluate arrhythmic events by analysis of the therapy-counter in combination with clinical symptoms. Even rapid ventricular tachyarrhythmias may not produce significant symptoms prior to ICD shock in more than 50% of patients. On the other hand the ICD device will initiate inappropriate therapy due to sensing error and non sustained tachyarrhythmias in 20–40% of patients. Third generation ICD devices provide sophisticated diagnostic information by stored electrograms. Intracardiac electrograms are recorded by the bipolar tip electrode of the sensing lead, located in the right ventricel (near field) or by the electrodes used for energy delivery (far field). These ECG recordings provide valuable information to evaluate the type of arrhythmia, trigger mechanisms and therapeutic efficacy. The arrhythmia leading to device therapy is judged by cycle length and stability and morphology of the intracardiac signal. A correct arrhythmia classification using electrogram analysis is possible in 92–98% of arrhythmias. Evaluation is limited in 5–10% of patients with bundle branch block or aberand conduction. Inappropriate ICD therapy is caused by atrial fibrillation in more than 50% and by supraventricular tachycardia or sinus tachycardia in about 20%. Sensing of artefacts can be attributed to lead failure in about 17%. The distinction between appropriate and inappropriate therapeutic intervention by the ICD allows the prevention of unnecessary shock delivery and early diagnosis of lead failure. The development of dual chamber systems with enhanced storage capacity and improved algorithms for detection of arrhythmias may further decrease the incidence of inappropriate ICD therapies.
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Müller, D., Hoffman, E., Fiek, M. et al. Bedeutung der Speicherelektrogramme zur Differenzierung adäquater und inadäquater ICD-Therapien. Herzschr Elektrophys 8, 39–45 (1997). https://doi.org/10.1007/BF03042476
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DOI: https://doi.org/10.1007/BF03042476