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Zur Rolle von Natriumselenit als Adjuvans in der Strahlentherapie des Rektumkarzinoms

The role of natrium selenite as adjuvans in radiotherapy of rectal cancer

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Summary

□Background: In various epidemiologic studies an association of low selenium blood levels and reduced glutathione peroxidase with an increased risk of cancer incidence was described. The antitumoral therapy and a suboptimal nutrition on could intensify this deficiency. Every reduction of disease related and therapeutic caused symptoms may improve life quality.

□Application: We report our preliminary experiences in the adjuvant radiochemotherapy of advanced rectal cancer (UICC II/III) corresponding to the NCI recommendation. An oral selenium supplementation was carried out with 2000 µg Na2SeO3 after every course of fluorouracial chemotherapy and daily 400 µg Na2SeO3 after irradiation of tumor region and lymph nodes. A weekly life quality assessment was explored with special interest in diarrhea, dysurie, pain, appetite, nausea and emesis.

□ Conclusion: Damages to normal tissue specially to DNA, encymes and membranes caused by free radicals is one mechanism in tumorgenesis, tumor progression and therapeutic consequence. A radioprotective effect of selenium is verified by in vitro and in vivo data. Our data show that oral selenium intake in rectal cancer patients is easily tolerated with no side effects. Improving life quality and secondary cancer prevention with supplementation of selenium has to be proven in prospective randomized studies.

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Authors and Affiliations

  1. Abteilung für Strahlentherapie CRONA B02, Radiologische Universitätsklinik, Hoppe-Seyler-Straße, D-72076, Tübingen

    Thomas Hehr, Wolfgang Hoffmann & Michael Bamberg

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  1. Thomas Hehr
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  2. Wolfgang Hoffmann
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  3. Michael Bamberg
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Correspondence to Thomas Hehr.

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Hehr, T., Hoffmann, W. & Bamberg, M. Zur Rolle von Natriumselenit als Adjuvans in der Strahlentherapie des Rektumkarzinoms. Med Klin 92 (Suppl 3), 48–49 (1997). https://doi.org/10.1007/BF03041966

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  • DOI: https://doi.org/10.1007/BF03041966

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