Abstract
Our objective was to appraise bronchial hyperresponsiveness in Sjögren’s syndrome (SS) and to analyze the clinical aspects of those patients. Forty-five patients with primary and secondary SS underwent examination with chest X-ray, spirometry and directly writing of the dose-response curve of respiratory resistance (Rrs) during the continuous inhalation of methacholine in stepwise incremental concentrations (astograph). Thirty-one patients (68.9%) had bronchial hyperresponsiveness. Ten out of 12 (83.3%) patients with extraglandular involvement had bronchial hyperresponsiveness. The threshold of the increase of Rrs in SS patients was significantly higher than bronchial asthma. This paper shows that some patients with SS have bronchial hyperresponsiveness; especially in patients with extraglandular involvement, it occurs at a high incidence. In addition, the pattern of the dose-response curve with bronchial hyperresponsiveness in SS was similar to that of chronic bronchitis rather than bronchial asthma in the methacholine inhalation test.
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References
Moutsopoulos HM, Chused TMet al.: Sjögren’s syndrome (sicca syndrome): current issues.Ann Intern Med 92: 212–226, 1980.
Moutsopoulos HM: Immunopathology of Sjögren’s syndrome: More questions than answers.Lupus 2: 209–211, 1993.
Baeiffi F, Pesci A, Bertorelli Get al.: Pulmonary involvement in Sjögren’s syndrome.Respiration 46: 82–87, 1984.
Strimlan CV, Rosenow EC III, Divertie MBet al.: Pulmonary maifestation of Sjögren’s syndrome.Chest 70: 354–361, 1976.
Potena A, LaCorte R, Fabbri LMet al.: Increased bronchial responsiveness in primary and secondary Sjögren’s syndrome.Eur Respir J 3: 548–553, 1990.
Gudbjörnsson B, Hedenström H, Stålenheim Het al.: Bronchial hyperresponsiveness to methacholine in patients with primary Sjögren’s syndrome.Ann Rheum Dis 50: 36–40, 1991.
LaCorte R, Potena A, Bajocci Get al.: Increased bronchial responsiveness in primary Sjögren’s syndrome. Asign of trachobronchial involvement.Clin Exp Rheum 9: 125–130, 1991.
Takishima T, Hida W, Sasaki Het al.: Direct-writing recorder of the dose-response curves of the airway to methacholine.Chest 80: 600–606, 1981.
Mita S, Kohno M, Matuoka Yet al.: Diagnostic availability of RI — sialography in Sjögren’s syndrome.The Ryumachi 11: 305–316, 1981.
Chai H, Farr RS, Froehlick LAet al.: Standardization of bronchial inhalation challenge proceduresJ Allergy Clin Immunol 56: 323–327, 1975.
Papathanasiou M, Constantopoulos SH, Tsampoulas Cet al.: Reappraisal of respiratory abnormalities in primary and secondary Sjögren’s syndrome. A control study.Chest 90: 370–374, 1986.
Hatron P-Y, Wallaert B, Gosset Det al.: Subclinical lung inflammation in primary Sjögren’s syndrome. Relationship between bronchoalveolar lavage cellular analysis findings and characteristics of the disease.Arthritis Rheum 30: 1226–1231, 1987.
Dalavanga YA, Constantopoulos SH, Galanopoulos Vet al.: Alveolitis correlates with clinical pulmonary involvement in primary Sjögren’s syndrome.Chest 99: 1394–1397, 1991.
Gilbard JP, Farris RL, Santamaria J II: Osmolality of tear microvolumes in keratoconjunctivitis sica.Arch Ophthalmol 96: 677–681, 1981.
Nahir AM, Szargel R, Scharf Jet al.: Chemical analysis of whole saliva in Sjögren’s syndrome.Ann Rheum Dis 46: 654–657, 1987.
Empey DW, Laitinen LA, Jacobs Let al.: Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection.Am Rev Respir Dis 113: 131–139, 1976.
Moutsopoulos HM: Sjögren’s syndrome: autoimmune epithelitis.Clin Immunol Immunopathol 72: 162–165, 1994.
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Ohmoto, A., Kohno, M., Ieko, M. et al. Bronchial hyperresponsiveness in Sjögren’s syndrome — relationship between extraglandular manifestation. Japanese Journal of Rheumatology 7, 271–278 (1997). https://doi.org/10.1007/BF03041329
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DOI: https://doi.org/10.1007/BF03041329