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ProgressiveStaphylococcus lugdunensis endocarditis despite antibiotic treatment

Progrediente infektiöse Endokarditis durch Staphylococcus lugdunensis trotz antibiotischer

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Zusammenfassung

Bei einem 68-jährigen Mann mit Fieber, Schüttelfrost und einem diastolischen Herzgeräusch wurde eine durch Staphylococcus lugdunensis verursachte Aortenklappenendokarditis diagnostiziert. Unter antibiotischer Therapie verbesserte sich das klinische Bild zunächst. Am siebten stationären Behandlungstag wurden große Abszesse mit transösophagealer Echokardiographie nachgewiesen, die sich von der Aortenwurzel bis zur freien Wand des linken Ventrikels ausdehnten. Der notfallmäßige operative Eingriff verlief erfolgreich und eine gerüstfreie Bioprothese wurde implantiert. Staphylococcus lugdunensis verursacht infektiöse Endokarditiden mit aggressivem klinischen Verlauf, die trotz adäquater antibiotischer Therapie zur Destruktion von Herzklappen, Abszedierung und embolischen Komplikationen neigen. Die hohe Letalität bei Patienten unter alleiniger antibiotischer Therapie kann durch frühzeitigen prothetischen Klappenersatz gesenkt werden.

Summary

A 68-year old man with fever chills and a diastolic murmur was diagnosed with aortic-valve endocarditis caused by coagulase-negativeStaphylococcus lugdunensis. The clinical condition initially improved with antibiotic therapy. On day seven, transoesophageal echocardiography revealed large abscesses extending from the aortic root to the left ventricular wall. Emergency cardiac surgery was performed successfully and a stentless bioprosthetic valve was inserted.S. lugdunensis endocarditis is known for its aggressive clinical course with valve destruction, abscess formation and embolic complications despite appropriate antibiotics. Antibiotic treatment alone is associated with a high mortality rate which can be reduced by early valve replacement.

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References

  1. Whitener C, Caputo GM, Weitekamp MR, Karchmer AW (1993) Endocarditis due to coagulase-negative staphylococci: microbiologic, epidemiologic and clinical considerations. Infect Dis Clin North Am 7: 81–96

    PubMed  CAS  Google Scholar 

  2. Ivert TS, Dismukes WE, Cobbs CG, Blackstone EH, Kirklin JW, Bergdahl LA (1984) Prosthetic valve endocarditis. Circulation 69: 223–232

    PubMed  CAS  Google Scholar 

  3. Horstkotte D, Piper C, Schultheiss HP (1997) Acute infectious endocarditis. Wien Klin Wochenschr 109: 105–115

    PubMed  CAS  Google Scholar 

  4. Kirchhoff LV, Sheagren JN (1985) Epidemiology and clinical significance of blood cultures positive for coagulase-negative staphylococcus. Infect Control 6: 479–486

    PubMed  CAS  Google Scholar 

  5. Fleurette J, Bes M, Brun Y, Freney J, Forey F, Coulet M, Reverdy ME, Etienne J (1989) Clinical isolates of Staphylococcus lugdunensis and S. schleiferi: bacteriological characteristics and susceptibility to antimicrobial agents. Res Microbiol140: 107–118

    Article  PubMed  CAS  Google Scholar 

  6. Castro JG, Dowdy L (1999) Septic shock caused by Staphylococcus lugdunensis. Clin Infect Dis 28: 681–682

    Article  PubMed  CAS  Google Scholar 

  7. Pareja J, Gupta K, Koziel H (1998) The toxic shock syndrome and Staphylococcus lugdunensis bacteremia. Ann Intern Med 128: 603–604

    PubMed  CAS  Google Scholar 

  8. Herchline TE, Ayers LW (1991) Occurrence of Staphylococcus lugdunensis in consecutive clinical cultures and relationship of isolation to infection. J Clin Microbiol 29: 419–421

    PubMed  CAS  Google Scholar 

  9. Shuttleworth R, Colby WD (1992) Staphylococcus lugdunensis endocarditis. J Clin Microbiol 30: 1948–1952

    PubMed  CAS  Google Scholar 

  10. Hébert GA (1990) Hemolysins and other characteristics that help differentiate and biotype Staphylococcus lugdunensis and Staphylococcus schleiferi. J Clin Microbiol 28: 2425–2431

    PubMed  Google Scholar 

  11. Herchline TE, Barnishan J, Ayers LW, Fass RJ (1990) Penicillinase production and in vitro susceptibilities of Staphylococcus lugdunensis. Antimicrob Agents Chemother 34: 2434–2435

    PubMed  CAS  Google Scholar 

  12. Vandenesch F, Etienne J, Reverdy ME, Eykyn SJ (1993) Endocarditis due toStaphylococcus lugdunensis: report of 11 cases and review. Clin Infect Dis 17: 871–876

    PubMed  CAS  Google Scholar 

  13. Patel R, Piper KE, Rouse MS, Uhl JR, Cockerill FR 3rd, Steckelberg JM (2000) Frequency of isolation of Staphylococcus lugdunensis among staphylococcal isolates causing endocarditis: a 20-year experience. J Clin Microbiol 38: 4262–4263

    PubMed  CAS  Google Scholar 

  14. Caputo GM, Archer GL, Calderwood SB, DiNubile MJ, Karchmer AW (1987) Native valve endocarditis due to coagulase-negative staphylococci: clinical and microbiologic features. Am J Med 83: 619–625

    Article  PubMed  CAS  Google Scholar 

  15. Wilson WR, Karchmer AW, Dajani AS, Taubert KA, Bayer A, Kaye D, Bisno AL, Ferrieri P, Shulman ST, Durack DT (1995) Antibiotic treatment of adults with infective endocarditis due to streptococci, enterococci, staphylococci, and HACEK microorganisms. American Heart Association. JAMA 274: 1706–1713

    Article  PubMed  CAS  Google Scholar 

  16. Petzsch M, Krause R, Reisinger E (2001) Current treatment options of infectious endocarditis. J Clin Basic Cardiology 4: 25–30

    CAS  Google Scholar 

  17. Arnett EN, Roberts WC (1976) Valve ring abscess in active infective endocarditis. Frequency, location, and clues to clinical diagnosis from the study of 95 necropsy patients. Circulation 54: 140–145

    PubMed  CAS  Google Scholar 

  18. Wang K, Gobel F, Gleason DF, Edwards JE (1972) Complete heart block complicating bacterial endocarditis. Circulation 46: 939–947

    PubMed  CAS  Google Scholar 

  19. Jaffe AS, Ravkilde J, Roberts R, Naslund U, Apple FS, Galvani M, Katus H (2000) It’s time for a change to a troponin standard. Circulation 102: 1216–1220

    PubMed  CAS  Google Scholar 

  20. Koh TW, Brecker SJ, Layton CA (1996) Successful treatment of Staphylococcus lugdunensis endocarditis complicated by multiple emboli: a case report and review of the literature. Int J Cardiol 55: 193–197

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Emil C. Reisinger M.D..

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Petzsch, M., Leber, W., Westphal, B. et al. ProgressiveStaphylococcus lugdunensis endocarditis despite antibiotic treatment. Wien Klin Wochenschr 116, 98–101 (2004). https://doi.org/10.1007/BF03040704

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  • DOI: https://doi.org/10.1007/BF03040704

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