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New drugs for BNCT: An experimental approach

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Summary

New kinds of boron-containing drugs were developed and tested in several murine tumor models. The boron-containing ether lipid B-Et-11-OMe was injected in mammary carcinoma (AT17) and osteosarcoma (OTS-64) bearing mice. Furthermore boron-substituted ferrocenium derivatives were tested. Two were excessively toxic; the third could be investigated. Boron accumulation and time-dependent biodistribution were determined using alpha-particle sensitive films and inductively coupled plasma-atomic emission pectrometry (ICP-AES) and-mass spectrometry (ICP-MS) of tumors, organs and tissues. Additionally, a new method of boron detection by NMR is in preparation.

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Authors and Affiliations

  1. DVM, Dept. of Radiation Oncology, Klinikum rechts der Isar, Ismaninger Str. 22, D-81675, Munich, Germany

    Lothar Weissfloch, Michael Bremer & Michael Molls

  2. Inst. for Organic Chemistry and Biochemistry, Graching, Germany

    Peter Lemmen

  3. Inst. for Radiochemistry, Garching, Germany

    Thomas Probst

  4. Inst. for Anorg. Chemistry, Garching, TU Munich, Austria

    Matthias Wagner

  5. Dept. of Nuclear Magnetic Resonance, Klinikum Grosshadern, LMU Munich, Germany

    Michael Peller

  6. Dept. of Radiotherapy-Radiooncology, University of Innsbruck, Austrial

    Thomas Auberger

  7. Dept. of Nuclear Medicine, Klinikum rechts der Isar, TU Munich, Germany

    Reingard Senekowitsch-Schmidtke

  8. Inst. for Pharmacology, Toxicology and Pharmacy, Faculty of Veterinary Medicine, LMU Munich, Germany

    Karlheinz Tempel

Authors
  1. Lothar Weissfloch
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  2. Michael Bremer
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  3. Peter Lemmen
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  4. Thomas Probst
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  5. Matthias Wagner
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  6. Michael Peller
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  7. Thomas Auberger
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  8. Reingard Senekowitsch-Schmidtke
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  9. Karlheinz Tempel
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  10. Michael Molls
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Correspondence to Lothar Weissfloch.

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Weissfloch, L., Bremer, M., Lemmen, P. et al. New drugs for BNCT: An experimental approach. Strahlenther Onkol 175 (Suppl 2), 118–120 (1999). https://doi.org/10.1007/BF03038909

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