Conditioning of cerebral dysrhythmia induced by Pattern Presentation and Eye Closure

Abstract

Previous communications from the Epilepsy Center of the University of Wisconsin described the conditioning of certain types of sensory-induced epilepsy. These included stroboscopic-induced seizures, startle epilepsy and musicogenic epilepsy. The present communication adds two types of sensory-evoked seizures treated by conditioning techniques. These additional types are the dysrhythmias induced by pattern presentation and by eye closure. The techniques employed are similar in their main concept to those previously reported. The presentation of a noxious stimulus is altered in such a way as to be innocuous, then is presented repeatedly without producing a seizure. Next, the stimulus is altered gradually until the noxious state is reached.

Although these techniques are of value in the treatment of refractory cases of sensory-evoked epilepsy, their major importance is the demonstration that it is possible by the use of behavioral techniques to alter the electroencephalogram and the neurophysiological-neurochemical state which is epilepsy.