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Rodent model systems for studies of HIV-1 associated dementia

  • Part II Experimental Models of Had
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Abstract

Understanding of HIV-1 neuropathogenesis and development of rationale therapeutic approaches requires relevant animal models. The putative mechanisms of neuroinflammatory and neurotoxic events triggered by HIV-1 brain infection are reflected by a number of rodent models. These include transgenic animals (either expressing viral proteins or pro-inflammatory factors), infection with murine retroviruses, and severe combined immunodeficient (SCID) mice reconstituted with human lymphocytes and injected intracerebrally with HIV-1-infected human monocyte-derived macrophages. The potential importance and limitations of the models in reflecting human disease are discussed with emphasis on their utility for development of therapies to combat HIV-1-associated neurologic impairment.

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Authors and Affiliations

  1. Center for Neurovirology and Neurodegenerative Disorders, Departments of Neuroscience, University of Nebraska Medical Center, 68198, Omaha, NE, USA

    Yuri Persidsky, Raghava Potula & James Haorah

  2. Center for Neurovirology and Neurodegenerative Disorders, Departments of Pathology and Microbiology, University of Nebraska Medical Center, 68198, Omaha, NE, USA

    Yuri Persidsky

  3. Center for Neurovirology and Neurodegenerative Disorders, Departments of Pharmacology, University of Nebraska Medical Center, 68198, Omaha, NE, USA

    Yuri Persidsky, Raghava Potula & James Haorah

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  1. Yuri Persidsky
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  2. Raghava Potula
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Correspondence to Yuri Persidsky.

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Persidsky, Y., Potula, R. & Haorah, J. Rodent model systems for studies of HIV-1 associated dementia. neurotox res 8, 91–106 (2005). https://doi.org/10.1007/BF03033822

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