The anhedonia hypothesis — that brain dopamine plays a critical role in the subjective pleasure associated with positive rewards — was intended to draw the attention of psychiatrists to the growing evidence that dopamine plays a critical role in the objective reinforcement and incentive motivation associated with food and water, brain stimulation reward, and psychomotor stimulant and opiate reward. The hypothesis called to attention the apparent paradox that neuroleptics, drugs used to treat a condition involving anhedonia (schizophrenia), attenuated in laboratory animals the positive reinforcement that we normally associate with pleasure. The hypothesis held only brief interest for psychiatrists, who pointed out that the animal studies reflected acute actions of neuroleptics whereas the treatment of schizophrenia appears to result from neuroadaptations to chronic neuroleptic administration, and that it is the positive symptoms of schizophrenia that neuroleptics alleviate, rather than the negative symptoms that include anhedonia. Perhaps for these reasons, the hypothesis has had minimal impact in the psychiatric literature. Despite its limited heuristic value for the understanding of schizophrenia, however, the anhedonia hypothesis has had major impact on biological theories of reinforcement, motivation, and addiction. Brain dopamine plays a very important role in reinforcement of response habits, conditioned preferences, and synaptic plasticity in cellular models of learning and memory. The notion that dopamine plays a dominant role in reinforcement is fundamental to the psychomotor stimulant theory of addiction, to most neuroadaptation theories of addiction, and to current theories of conditioned reinforcement and reward prediction. Properly understood, it is also fundamental to recent theories of incentive motivation.
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Ahlenius S (1985) A functional consideration of anatomical connections between the basal ganglia and the thalamus suggests that antipsychotic drugs inhibit the initiation of movement.Behav. Brain Sci. 8, 173–174.
Axelrod J (1970) Amphetamine: metabolism, physiological disposition, and its effects on catecholamine storage, In:Amphetamines and Related Compounds (Costa E and S Garattini, Eds.) (Raven Press:New York), pp 207–216.
Baldo BA and AE Kelley (2007) Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding.Psychopharmacol. 191, 439–459.
Bellmaker RH and D Wald (1977) Haloperidol in normalsBr. J. Psychiatry 131, 222–223.
Berridge KC (2000) Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns.Neurosci. Biobehav. Rev. 24, 173–198.
Berridge KC and HJ Grill (1984) Isohedonic tastes support a two-dimensional hypothesis of palatability.Appetite 5, 221–231.
Berridge KC and TE Robinson (1998) What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?Brain Res. Rev. 28, 309–369.
Bielajew C and P Shizgal (1986) Evidence implicating descending fibers in self-stimulation of the medial forebrain bundle.J. Neurosci. 6, 919–929.
Bijerot N (1980) Addiction to pleasure: a biological and social-psychological theory of addiction, In:Theories on Drug Abuse:Selected Contemporary Perspectives (Lettieri DJ, M Sayersand & HW Pearson, Eds.) (National Institute on Drug Abuse, Rockville, MD), pp 246–255.
Bloom FE and ELF Battenberg (1976) A rapid, simple and sensitive method for the demonstration of central catecholamine-containing neurons and axons by glyoxylic acid-induced fluorescence. II. A detailed description of methodology.J. Histochem. Cytochem. 24, 561–571.
Bozarth MA and RA Wise (1981) Intracranial self-administration of morphine into the ventral tegmental area in rats.Life Sci. 28, 551–555.
Brauer LH and H de Wit (1996) Subjective responses to d-amphet-amine alone and after pimozide pretreatment in normal, healthy volunteers.Biol. Psychiatry 39, 26–32.
Brauer LH and H de Wit (1997) High dose pimozide does not block amphetamine-inducedeuphoria innormal volunteers.Pharmacol. Biochem. Behav. 56, 265–272.
Broekkamp CLE, JH Van den Bogaard, HJ Heijnen, RH Rops, AR Cools and JM Van Rossum (1976) Separation of inhibiting and stimulating effects of morphine on self-stimulation behavior by intracerebral microinjections.Eur. J. Pharmacol. 36, 443–446.
Carlezon WA Jr, DP Devine and RA Wise (1995) Habit-forming actions of nomifensine in nucleus accumbens.Psychopharmacol. 122, 194–197.
Carlsson A (1959) The occurrence, distribution and physiological role of catecholamines in the nervous system.Pharmacol. Rev. 11, 90–493.
Carlsson A (1970) Amphetamine and brain catecholamines, In:Amphetamines and Related Compounds (Costa E & S Garattini, Eds.) (Raven Press:New York), pp 289–300.
Carlsson A, M Lindqvist, T Magnusson and B Waldeck (1958) On the presence of 3-hydroxytyramine in brain.Science 127, 471.
Carlsson A, B Falck and N Hillarp (1962) Cellular localization of brain monoamines.Acta Physiol. Scand. Suppl.56, 1–28.
Centonze D, B Picconi, P Gubellini, G Bernard and P Calabresi (2001) Dopaminergic control of synaptic plasticity in the dorsal striatum.Eur. J. Neurosci. 13, 1071–1077.
Colpaert F, W Koek, M Kleven and J Besnard (2007) Induction by antipsychotics of “win-shift” in the drug discrimination paradigm.J. Pharmacol. Exp. Ther. 322, 288–298.
Corbett D and RA Wise (1979) Intracranial self-stimulation in relation to the ascending noradrenergic fiber systems of the pontine tegmentum and caudal midbrain: a moveable electrode mapping study.Brain Res. 177, 423–436.
Corbett D and RA Wise (1980) Intracranial self-stimulation in relation to the ascending dopaminergic systems of the midbrain: a moveable electrode mapping study.Brain Res. 185, 1–15.
Corbett D, RW Skelton and RA Wise (1977) Dorsal noradrenergic bundle lesions fail to disrupt self-stimulation from the region of locus coeruleus.Brain Res. 133, 37–44.
Crow TJ (1972) A map of the rat mesencephalon for electrical self-stimulation.Brain Res. 36, 265–273.
Crow TJ, PJ Spear and GW Arbuthnott (1972) Intracranial self-stimulation with electrodes in the region of the locus coeruleus.Brain Res. 36, 275–287.
de Wit H and J Stewart (1983) Drug reinstatement of heroin-reinforced responding in the rat.Psychopharmacol. 79, 29–31.
de Wit H and RA Wise (1977) Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.Can. J. Psychol. 31, 195–203.
Edmonds DE and CR Gallistel (1974) Parametric analysis of brain stimulation reward in the rat: III. Effect of performance variables on the reward summation function.J. Comp. Physiol. Psychol. 87, 876–883.
Ettenberg A and CH Camp (1986a) A partial reinforcement extinction effect in water-reinforced rats intermittently treated with haloperidol.Pharmacol. Biochem. Behav. 25, 1231–1235.
Ettenberg A and CH Camp (1986b) Haloperidol induces a partial reinforcement extinction effect in rats: implications for dopamine involvement in food reward.Pharmacol. Biochem. Behav. 25, 813–821.
Ferre S, BB Fredholm, M Morelli, P Popoli and K Fuxe (1997) Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia.Trends Neurosci. 20, 482–487.
Fibiger HC (1978) Drugs and reinforcement mechanisms: a critical review of the catecholamine theory.Annu. Rev. Pharmacol. Toxicol. 18, 37–56.
Fibiger HC, DA Carter and AG Phillips (1976) Decreased intracranial self-stimulation after neuroleptics or 6-hydroxydopamine: evidence for mediation by motor deficits rather than by reduced reward.Psychopharmacol. 47, 21–27.
Fouriezos G (1985) Sedation-induced jumping?Behav. Brain Sci. 8, 174–175.
Fouriezos G and RA Wise (1976) Pimozide-induced extinction of intracranial self-stimulation: response patterns rule out motor or performance deficits.Brain Res. 103, 377–380.
Fouriezos G, P Hansson and RA Wise (1978) Neuroleptic-induced attenuation of brain stimulation reward in rats.J. Comp. Physiol. Psychol. 92, 661–671.
Franklin KBJ (1978) Catecholamines and self-stimulation: reward and performance effects dissociated.Pharmacol. Biochem. Behav. 9, 813–820.
Franklin KBJ and SN McCoy (1979) Pimozide-induced extinction in rats: stimulus control of responding rules out motor deficit.Pharmacol. Biochem. Behav. 11, 71–75.
Freed WJ and RF Zec (1982) Criteria for ruling out sedation as an interpretation of neuroleptic effects.Behav. Brain Sci. 5, 57–59.
Gallistel CR and D Karras (1984) Pimozide and amphetamine have opposing effects on the reward summation function.Pharmacol. Biochem. Behav. 20, 73–77.
Gallistel CR, P Shizgal and J Yeomans (1981) A portrait of the substrate for self-stimulation.Psychol. Rev. 88, 228–273.
Gallistel CR, M Boytim, Y Gomita and L Klebanoff (1982) Does pimozide block the reinforcing effect of brain stimulation?Pharmacol. Biochem. Behav. 17, 769–781.
German DC and DM Bowden (1974) Catecholamine systems as the neural substrate for intracranial self-stimulation: a hypothesis.Brain Res. 73, 381–419.
Goeders NE and JE Smith (1983) Cortical dopaminergic involvement in cocaine reinforcement.Science 221, 773–775.
Goeders NE, SIDworkinand JE Smith(1986)Neuropharmacological assessment of cocaine self-administration into the medial pre-frontal cortex.Pharmacol. Biochem. Behav. 24, 1429–1440.
Grace AA (2000) The tonic/phasic model of dopamine system regulation and its implications for understanding alcohol and stimulant craving.Addiction 95, S119-S128.
Gramling SE, SC Fowler and KR Collins (1984) Some effects of pimozide on nondeprived rats licking sucrose solutions in an anhedonia paradigm.Pharmacol. Biochem. Behav. 21, 617–624.
Greengard P (1976) Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters.Nature 260, 101–108.
Grill HJ and R Norgren (1978) The taste reactivity test. II. Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats.Brain Res. 143, 281–297.
Gunne LM, E Änggard E and LE Jönsson (1972) Clinical trials with amphetamine-blocking drugs.Psychiatr. Neurol. Neurochirurg. 75, 225–226.
Gysling K and RY Wang (1983) Morphine-induced activation of A10 dopamine neurons in the rat.Brain Res. 277, 119–127.
Healy D (1989) Neuroleptics and psychic indifference: a review.J. Royal Soc. Med. 82, 615–619.
Heath RG (1963) Intracranial self-stimulation in man.Science 140, 394–396.
Heath RG (1972) Pleasure and brain activity in man.J. Nerv. Ment. Disord. 154, 3–18.
Hollister LE, DT Eikenberry and S Raffel (1960) Chlorprom-azine in nonpsychotic patients with pulmonary tuberculosis.Am. Rev. Resp. Dis. 82, 562–566.
Hornykiewicz O (1979) Brain dopamine in Parkinson’s disease and other neurological disturbances, In:The Neurobiology of Dopamine (Horn AS, J Korf & BHC Westerink, Eds.) (Academic Press:New York), pp 633–653.
Howarth CI and JA Deutsch (1962) Drive decay: the cause of fast “extinction” of habits learned for brain stimulation.Science 137, 35–36.
Hyman SE, RC Malenka and EJ Nestler (2006) Neural mechanisms of addiction: the role of reward-related learning and memory.Annu. Rev. Neurosci. 29, 565–598.
Ikemoto S (2003) Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies.J. Neurosci. 23, 9305–9511.
Johnson SW and RA North (1992) Opioids excite dopamine neurons by hyperpolarization of local interneurons.J. Neurosci. 12, 483–488.
Jönsson L, E Änggard and L Gunne L (1971) Blockade of intravenous amphetamine euphoria in man.Clin. Pharmacol. Ther. 12, 889–896.
Katz LD (1982) Hedonic arousal, memory, and motivation.Behav. Brain Sci. 5, 60.
Kelleher RT and WH Morse (1968) Schedules using noxious stimuli. 3. Responding maintained with response produced electric shocks.J. Exp. Anal. Behav. 11, 819–838.
Koob GF (1982) The dopamine anhedonia hypothesis: a pharmacological phrenology.Behav. Brain Sci. 5, 63–64.
Kornetsky C (1985) Neuroleptic drugs may attenuate pleasure in the operant chamber, but in the schizophrenic’s head they may simply reduce motivational arousal.Behav. Brain Sci. 8, 176–177.
Landauer TK (1969) Reinforcement as consolidation.Psychol. Rev. 76, 82–96.
Lepore M and KBJ Franklin (1992) Modelling drug kinetics with brain stimulation: dopamine antagonists increase self-stimulation.Pharmacol. Biochem. Behav. 41, 489–496.
Liebman J (1982) Understanding neuroleptics: From “anhedonia” to “neuroleptothesia”.Behav. Brain Sci. 5, 64–65.
Ljungberg T, P Apicella and W Schultz (1992) Responses of monkey dopamine neurons during learning of behavioral reactions.J. Neurophysiol. 67, 145–163.
Mason ST, RJ Beninger, HC Fibiger and AG Phillips (1980) Pimozide-induced suppression of responding: evidence against a block of food reward.Pharmacol. Biochem. Behav. 12, 917–923.
Matthews RT and DC German (1984) Electrophysiological evidence for excitation of rat ventral tegmental area dopaminergic neurons by morphine.Neurosci. 11, 617–626.
McFarland K and A Ettenberg (1995) Haloperidol differentially affects reinforcement and motivational processes in rats running an alley for intravenous heroin.Psychopharmacol. 122, 346–350.
McFarland K and A Ettenberg (1998) Haloperidol does not affect motivational processes in an operant runway model of food-seeking behavior.Behav. Neurosci. 112, 630–635.
Mogenson GJ, DL Jones and A Ettenberg CY Yim (1980) From motivation to action: functional interface between the limbic system and the motor system.Prog. Neurobiol. 14, 69–97.
Morgan MJ (1974) Resistance to satiation.Animal Behav. 22, 449–466.
Nauta WJH, A Ettenberg and VB Domesick (1978a) Crossroads of limbic and striatal circuitry: hypothalamo-nigral connections, In:Limbic Mechanisms (Livingston KE & O Hornykiewicz, Eds.) (Plenum Press:New York), pp 75–93.
Nauta WJH, GP Smith, RLM Faull and VB Domesick (1978b) Efferent connections and nigral afferents of the nucleus accumbens septi in the rat.Neurosci. 3, 385–401.
Olds J (1956) Pleasure centers in the brain.Sci. Am. 195, 105–116.
Olds J (1959) Self-stimulation experiments and differentiated reward systems, In:Reticular Formation of the Brain (Jasper H, LD Proctor, RS Knighton, WC Noshay & RT Costello, Eds.) (Little, Brown and Company:Boston), pp 671–687.
Olds J and PM Milner (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.J. Comp. Physiol. Psychol. 47, 419–427.
Olds ME and J Olds (1963) Approach-avoidance analysis of rat diencephalon.J. Comp. Neurol. 120, 259–295.
Olds J and ME Olds (1965) Drives, rewards, and the brain, In:New Directions in Psychology (TM Newcombe, Ed.) (Holt, Rinehart and Winston:New York), pp 327–410.
Olds J and RP Travis (1960) Effects of chlorpromazine, meprobamate, pentobarbital andmorphine on self-stimulation.J. Pharmacol. Exp. Ther. 128, 397–404.
Pavlov IP (1928)Lectures on Conditioned Reflexes (International Publishers:New York).
Pecina S, KC Berridge and LA Parker (1997) Pimozide does not shift palatability: separation of anhedonia from sensorimotor suppression by taste reactivity.Pharmacol. Biochem. Behav. 58, 801–811.
Phillips AG and HC Fibiger (1973) Dopaminergic and noradrenergic substrates of positive reinforcement: differential effects of d- and l-amphetamine.Science 179, 575–577.
Phillips AG and FG LePiane (1980) Reinforcing effects of morphine microinjection into the ventral tegmental area.Pharmacol. Biochem. Behav. 12, 965–968.
Pickens R and WC Harris (1968) Self-administration of d-amphetamine by rats. Psychopharmacologia12, 158–163.
Quinlan MG, R Sharf, DY Lee, RA Wise and R Ranaldi (2004) Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats.Psychopharmacol. 175, 53–59.
Ranaldi R and RA Wise (2001) Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine.J. Neurosci. 21, 5841–5846.
Rech R (1982) Neurolepsis: anhedonia or blunting of emotional reactivity.Behav. Brain Sci. 5, 72–73.
Reynolds JN, BI Hyland and JR Wickens (2001) A cellular mechanism of reward-related learning. Nature413, 67–70.
Risner ME and BE Jones (1976) Role of noradrenergic and dopaminergic processes in amphetamine self-administration.Pharmacol. Biochem. Behav. 5, 477–482.
Risner ME and BE Jones (1980) Intravenous self-administration of cocaine and norcocaine by dogs.Psychopharmacol. 71, 83–89.
Robbins D (1971) Partial reinforcement: a selective review of the alleyway literature since 1960.Psychol. Bull. 76, 415–431.
Roberts DCS, ME Corcoran and HC Fibiger (1977) On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine.Pharmacol. Biochem. Behav. 6, 615–620.
Robinson S, SM Sandstrom, VH Denenberg and RD Palmiter (2005) Distinguishing whether dopamine regulates liking, wanting, and/or learning about rewards.Behav. Neurosci. 119, 5–15.
Roll SK (1970) Intracranial self-stimulation and wakefulness: effect of manipulating ambient brain catecholamines.Science 168, 1370–1372.
7Romo R and W Schultz (1990) Dopamine neurons of the monkey midbrain: contingencies of responses to active touch during self-initiated arm movements.J. Neurophysiol. 63, 592–606.
Salamone JD and M Correa (2002) Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine.Behav. Brain Res. 137, 3–25.
Salamone JD, MS Cousins and S Bucher (1994) Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure.Behav. Brain Res. 65, 221–229.
Salamone JD, MS Cousins and BJ Snyder (1997) Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis.Neurosci. Biobehav. Rev. 21, 341–359.
Salamone JD, M Correa, S Mingote and SM Weber (2003) Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: implications for studies of natural motivation, psychiatry, and drug abuse.J. Pharmacol. Exp. Ther. 305, 1–8.
Salamone JD, M Correa, SM Mingote and SM Weber (2005) Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine.Curr. Opin. Pharmacol. 5, 34–41.
Schiffmann SN, G Fisone, R Moresco, RA Cunha and S Ferré (2007) Adenosine A2A receptors and basal ganglia physiology. Prog. Neurobiol. 83(5) 277–292. Epub 2007 June 26.
Schultz W (1998) Predictive reward signal of dopamine neurons.J. Neurophysiol. 80, 1–27.
Sclafani A and K Ackroff (1994) Glucose-and fructose-conditioned flavor preferences in rats: taste versus postingestive conditioning.Physiol. Behav. 56, 399–405.
Sem-Jacobsen CW (1959) Depth-electrographic observations in psychotic patients: a system related to emotion and behavior.Acta Psychiatr. Scand. Suppl.34, 412–416.
Skinner BF (1937) Two types of conditioned reflex: a reply to Konorski and Miller.J. Gen. Psychol. 16, 272–279.
Snyder SH, JJ Katims, Z Annau, RF Bruns and JW Daly (1981) Adenosine receptors and behavioral actions of methylxanthines.Proc. Natl. Acad. Sci. USA 78, 3260–3264.
Stein L (1962) Effects and interactions of imipramine, chlorpromazine, reserpine and amphetamine on self-stimulation: possible neurophysiological basis of depression, InRecent Advances in Biological Psychiaty (Wortis J, Ed.) (Plenum:New York), pp 288–308.
Stein L (1968) Chemistry of reward and punishment, In:Proceedings of the American College of NeuroPsychophar-macology (Efron DH, Ed.) (U.S. Government Printing Office:Washington, DC), pp 105–123.
Steiner JE (1973) The gustofacial response: observation on normal and anencephalic newborn infants.Symp. Oral Sensat. Percept. 4, 254–278.
Steiner JE (1974) Innate, discriminative human facial expressions to taste and smell stimulation.Ann. NY Acad. Sci. 237, 229–233.
Stretch R and GJ Gerber (1973) Drug-induced reinstatement of amphetamine self-administation behaviour in monkeys.Can. J. Psychol. 27, 168–177.
Stricker EM and MJ Zigmond (1974) Effects on homeostasis of intraventricular injections of 6-hydroxydopamine in rats.J. Comp. Physiol. Psychol. 86, 973–994.
Stricker EM, MB Zimmerman, MI Friedman and MJ Zigmond (1977) Caffeine restores feeding response to 2-deoxy-D-glucose in 6-hydroxydopamine-treated rats.Nature 267, 174–175.
Teitelbaum P and AN Epstein (1962) The lateral hypothalamic syndrome: recovery of feeding and drinking after lateral hypothalamic lesions.Psychol. Rev. 69, 74–90.
Thorndike EL (1898) Animal intelligence: an experimental study of the associative processes in animals.Psychol. Monogr. 8, 1–109.
Thorndike EL (1911)Animal Intelligence (Macmillan:New York).
Tombaugh TN, J Tombaugh and H Anisman (1979) Effects of dopamine receptor blockade on alimentary behaviors: home cage food consumption, magazine training, operant acquisition, and performance.Psychopharmacol. 66, 219–225.
Treit D and KC Berridge (1990) A comparison of benzodiazepine, serotonin, and dopamine agents in the taste-reactivity paradigm.Pharmacol. Biochem. Behav. 37, 451–456.
Ungerstedt U (1971) Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system.Acta Physiol. Scand. Suppl.367, 95–122.
vanRossum JM, JB van der Schoot JB and JA Hurkmans (1962) Mechanism of action of cocaine and amphetamine in the brain.Experientia 18, 229–230.
Volkow ND and JM Swanson (2003) Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD.Am. J. Psychiatry 160, 1909–1918.
White NM (1989) Reward or reinforcement: what’s the difference?Neurosci. Biobehav. Rev. 13, 181–186.
White NM and PM Milner (1992) The psychobiology of reinforcers.Annu. Rev. Psychol. 43, 443–471.
White NM and M Viaud (1991) Localized intracaudate dopamine D2 receptor activation during the post-training period improves memory for visual or olfactory conditioned emotional responses in rats.Behav. Neural Biol. 55, 255–269.
Wickens JR, JC Horvitz, RM Costa and S Killcross (2007) Dopaminergic mechanisms in actions and habits.J. Neurosci. 27, 8181–8183.
Wise CD and L Stein (1969) Facilitation of brain self-stimulation by central administration of norepinephrine.Science 163, 299–301.
Wise CD and L Stein (1970) Amphetamine: facilitation of behavior by augmented release of norepinephrine from the medial forebrain bundle,. In:Amphetamines and Related Compounds (Costa E and S Garattini, Eds.) (Raven Press:New York), pp 463–485.
Wise RA (1976) Moveable electrode for chronic brain stimulation in the rat.Physiol. Behav. 16, 105–106.
Wise RA (1978) Catecholamine theories of reward: a critical review.Brain Res. 152, 215–247.
Wise RA (1981) Intracranial self-stimulation: mapping against the lateral boundaries of the dopaminergic cells of the substantia nigra.Brain Res. 213, 190–194.
Wise RA (1982) Neuroleptics and operant behavior: the anhedonia hypothesis.Behav. Brain Sci. 5, 39–87.
Wise RA (1985) The anhedonia hypothesis: Mark III.Behav. Brain Sci. 8, 178–186.
Wise RA (1989) The brain and reward, In:The Neuropharmacological Basis of Reward (Liebmanand JM & SJ Cooper, Eds) (Oxford University Press:Oxford), pp 377–424.
Wise RA (1990) Drugs against pleasure.Curr. Contents 22, 20.
Wise RA (2002) Brain reward circuitry: insights from unsensed incentives.Neuron 36, 229–240.
Wise RA (2004) Dopamine, learning and motivation.Nat. Rev. Neurosci. 5, 483–494.
Wise RA and LM Colle (1984) Pimozide attenuates free feeding: best scores analysis reveals a motivational deficit.Psychopharmacol. 84, 446–451.
Wise RA and L Raptis (1986) Effects of naloxone and pimozide on initiation and maintenance measures of free feeding.Brain Res. 368, 62–68.
Wise RA and HV Schwartz (1981) Pimozide attenuates acquisition of lever pressing for food in rats.Pharmacol. Biochem. Behav. 15, 655–656.
Wise RA, J Spindler, H de Wit and GJ Gerber (1978) Neuroleptic-induced “anhedonia” in rats: pimozide blocks reward quality of food.Science 201, 262–264.
Wise RA, A Murray and MA Bozarth (1990) Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats.Psychopharmacol. 100, 355–360.
Yeomans JS, NT Maidment and BS Bunney (1988) Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cells.Brain Res. 450, 86–93.
Yokel RA and RA Wise (1975) Increased lever pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward.Science 187, 547–549.
Yokel RA and RA Wise (1976) Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats.Psychopharmacol. 48, 311–318.
Zigmond MJ and EM Stricker (1989) Animal models of parkinsonism using selective neurotoxins: clinical and basic implications.Int. Rev. Neurobiol. 31, 1–79.
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Wise, R.A. Dopamine and reward: The anhedonia hypothesis 30 years on. neurotox res 14, 169–183 (2008). https://doi.org/10.1007/BF03033808