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What is the mechanism whereby cannabis use increases risk of psychosis?

Neurotoxicity Research volume 14, pages 105–112 (2008)Cite this article

Abstract

Cannabis use has increased greatly over the last three decades. The various types of cannabis differ in their concentration of the main psychoactive component, Δ9-tetrahydrocannabinol (THC), and the other major ingredient, cannabidiol (CBD). Plant engineering has maximized levels of THC, thus increasing the potency of street cannabis. It is well known that cannabis intoxication can cause brief psychotic symptoms like paranoia, whilst recent evidence demonstrates that heavy use of cannabis increases the risk of chronic psychoses like schizophrenia; genetic vulnerability seems to predispose some people to a higher risk. This paper starts to consider the neurochemical mechanisms whereby cannabis use increases the risk of psychosis.

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Authors and Affiliations

  1. Division of Psychological Medicine, Institute of Psychiatry, Denmark Hill, SE5 8AF, London, UK

    Sonija Luzi, Paul D. Morrison, John Powell, Marta Di Forti & Robin M. Murray

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  1. Sonija Luzi
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  2. Paul D. Morrison
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  3. John Powell
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  4. Marta Di Forti
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  5. Robin M. Murray
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Correspondence to Robin M. Murray.

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Luzi, S., Morrison, P.D., Powell, J. et al. What is the mechanism whereby cannabis use increases risk of psychosis?. neurotox res 14, 105–112 (2008). https://doi.org/10.1007/BF03033802

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  • DOI: https://doi.org/10.1007/BF03033802

Keywords

  • Cannabis
  • Psychosis
  • Endocannabinoid System
  • Dopamine