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The role of adrenochrome in stimulating the oxidation of catecholamines

Neurotoxicity Research volume 1, pages 71–80 (1999)Cite this article

Abstract

Adrenochrome, a stable oxidation product formed after oxidation of adrenaline, strongly stimulates oxygen uptake occurring during the autoxidation of adrenaline, other catecholamines and ascorbate. Oxygen consumed is converted to hydrogen peroxide suggesting the occurrence of a redox cycling process. The reduction of adrenochrome operated by adrenaline is accelerated by the exclusion of oxygen indicating that the oxidation of adrenaline occurs directly and superoxide anion does not necessarily mediate it. Oxygen consumption, observed in the catecholamine/adrenochrome and ascorbate/adrenochrome systems, is due to the autoxidation of leucoadrenochrome that, at variance with adrenaline, easily autoxidizes also at physiological pH. Therefore, in these systems, leucoadrenochrome appears to be the major determinant of the production of superoxide anion.

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Abbreviations

DTPA:

diethylenetriamine pentaacetic acid

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Affiliations

  1. Centro Studio Biomembrane, CNR, Padova, Italy

    Alberto Bindoli

  2. Dipartimento di Chimica Biologica, Università di Padova, Viale G. Colombo 3, 35121, Padova, Italy

    Alberto Bindoli, Guido Scutari & Maria Pia Rigobello

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  1. Alberto Bindoli
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  2. Guido Scutari
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  3. Maria Pia Rigobello
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Correspondence to Alberto Bindoli.

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Bindoli, A., Scutari, G. & Rigobello, M.P. The role of adrenochrome in stimulating the oxidation of catecholamines. neurotox res 1, 71–80 (1999). https://doi.org/10.1007/BF03033271

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  • DOI: https://doi.org/10.1007/BF03033271

Keywords

  • Adrenaline
  • Adrenochrome
  • Aminochromes
  • Ascorbate
  • Catecholamine oxidation
  • Redox cycling