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Assessment of neurotoxicity following repeated cremophor / ethanol injections in rats

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Abstract

As the mixture cremophor/ethanol is known to have side-effects affecting the peripheral nervous system, we have assessed its behavioural and morphological neurotoxicity after repeated intraperitoneal injections in male Sprague Dawley rats. Clinical status of the animals was good throughout the experiment and no motor deficits were observed. Nevertheless, sensory testing demonstrated an hyperalgesia and an allodynia to mechanical stimuli, associated to peripheral axon degeneration.

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Authors and Affiliations

  1. Laboratoire de Toxicologic, Equipe NeuroPsychoPharmacologic Univcrsité d’ Auvergne (INSERM EMI 9904), 63001, Clermont-Ferrand, France

    Nicolas Authier & François Coudore

  2. Laboratoire de Pharmacologic, Faculté de Pharmacie, Equipe NeuroPsychoPharmacologic Univcrsité d’ Auvergne (INSERM EMI 9904), 63001, Clermont-Ferrand, France

    Joseph Fialip

  3. Laboratoire de Pharmacologic Médicale, Faculté de Médecine, Equipe NeuroPsychoPharmacologic Univcrsité d’ Auvergne (INSERM EMI 9904), 63001, Clermont-Ferrand, France

    Alain Eschalier

  4. Centre de Recherche, 63200, Riom, France

    Jean-Pierre Gillet

Authors
  1. Nicolas Authier
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  2. Jean-Pierre Gillet
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  3. Joseph Fialip
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  4. Alain Eschalier
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  5. François Coudore
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Correspondence to François Coudore.

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Authier, N., Gillet, JP., Fialip, J. et al. Assessment of neurotoxicity following repeated cremophor / ethanol injections in rats. neurotox res 3, 301–306 (2001). https://doi.org/10.1007/BF03033269

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  • DOI: https://doi.org/10.1007/BF03033269

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