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Lack of hydroxyl radical generation upon central administration of methamphetamine in rat caudate nucleus: A microdialysis study

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Abstract

The most widely accepted concept of oxidative damage centers on the formation of hydroxyl radical (OH) which has an extremely short-life and is the major damaging free radical. It was suggested that methamphetamine (METH) toxicity is mediated via production of OH, as measured by 2,3-dihydroxy-benzoic acid (2,3-DHBA). In this study we compared the effects of local caudate nucleus perfusion of METH with systemic administration of METH on OH generation in relation to DA release. Local perfusion of METH (5 mM,140 min) induced a higher level of dopamine (DA) release compared to the first METH injection (10 mg/kg, 3 times, i.p.). No significant correlation was found between changes in extracellular DA levels and OH generation when perfusing METH locally; however, both increased after systemic METH administration.

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Authors and Affiliations

  1. Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, NCTR/FDA, 72079, Jefferson, AR, USA

    Frederico C. Pereira, Syed Z. Imam & Syed F. Ali

  2. Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Coimbra, Portugal

    Frederico C. Pereira, Tice R. Macedo & Carlos F. Ribeiro

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  1. Frederico C. Pereira
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  2. Tice R. Macedo
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  3. Syed Z. Imam
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  4. Carlos F. Ribeiro
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  5. Syed F. Ali
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Correspondence to Syed F. Ali.

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Pereira, F.C., Macedo, T.R., Imam, S.Z. et al. Lack of hydroxyl radical generation upon central administration of methamphetamine in rat caudate nucleus: A microdialysis study. neurotox res 6, 149–152 (2004). https://doi.org/10.1007/BF03033217

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  • DOI: https://doi.org/10.1007/BF03033217

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