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Papillary microcarcinoma of the thyroid gland in renal transplant patients

Case reports and review of the literature

Pathology Oncology Research volume 6, pages 72–75 (2000)Cite this article

Abstract

Among organ transplant recipients there is a world wide increase in the number of de novo tumors as well as a decrease in the time of the first appearance after the transplantation. Between 1973 and the 31th of August 1999 1709 cadaver renal allograft transplantations were perfomed in our Department. Four thyroid cancers were detected among the renal transplanted patients. Two of them proved to be papillary microcarcinomas. Although the elevated risk of thyroid cancers is well established in the literature papillary microcarcinomas have never been reported before in an immunosuppressed patient. Authors highlight that the thyroid gland should always be carefully checked in organ transplant recipients, since better survival might be achieve even in the immunosuppressed population. Metastatic tumor is relatively benign which is in correlation with the literature, but there has been little experience in organ transplanted patients so far.

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References

  1. Auteliano F, Spagnoli LG, Santeusinaio G, et al: Occult carcinoma of the thyroid gland: an epidemiological study of autopsy material. Ann Ital Chir 61:141–146, 1990.

    Google Scholar 

  2. Brunner FP, Landais P, Seiwood NH: Malignancies after renal transplantation: the EDTA-ERA registry experience. European Dialysis and Transplantation Association-European Renal Association. Nephrol Dial Transplant 10:74–80, (suppl 1), 1995.

    PubMed  Google Scholar 

  3. Buccianti G, Maisonneuve P, Ravasi B, et al: Cancer among patients on renal replacement therapy: a population based survey in Lombardi, Italy. Int J Cancer 66:591–593, 1996.

    Article  PubMed  CAS  Google Scholar 

  4. Carcangiu ML, Zampi G, Pupi A, et al: (1985) Papillary Carcinoma of the thyroid. A clinicopathologic Study of 241 Cases Treated at the Universitiy of Florence, Italy. Cancer 55:805–828, 1985.

    CAS  Google Scholar 

  5. Engel U, Kucharski A, Zornig C: Eingeschrankte Radikalitat bei differezierten Schilddrüsencarcinomen. Eine prospektive Studie an 107 Patienten. Chirurg 65:1095–1098, 1994.

    PubMed  CAS  Google Scholar 

  6. Ésik O, Szentirmay Z, Tusnády G, et al: Malignus pajzsmirigytumorok Magyarországon:morbiditás és mortalités (Malignant thyroid tumors in Hungary:morbidity and mortality) Orv Hetil 137:905–911, 1996.

    PubMed  Google Scholar 

  7. Fahey TJ 3rd, Reeve TS, Delbridge L: Increasing incidence and changing presentation of thyroid cancer over a 30 year period. Br J Surg 82:518–20, 1995.

    Article  PubMed  Google Scholar 

  8. Franceschi S, La Vecchia C: Thyroid cancer. Cancer Surv 19-20:393–422, 1994.

    PubMed  CAS  Google Scholar 

  9. Hazard JB. Small papillary carcinoma of the thyroid: A study with special reference to so-called non-encapsulated sclerosing tumor. Lab Invest 8:86–97, 1960.

    Google Scholar 

  10. Hedinger C: Histological typing of thyroid tumors (2nd edition) Springer-Verlag, Berlin. Heidelberg, New York, London, Paris, Tokyo, 1988.

    Google Scholar 

  11. Hefer T, Joachims HZ, Eitan A, et al: Are the morphology of papillary thyroid carcinoma and the tumor’s behavior correlated? J Laryngol Otol 110:704–705, 1996.

    Article  PubMed  CAS  Google Scholar 

  12. Klinck GH, Winship T: Occult sclerosing carcinoma of the thyroid. Cancer 8:701–766, 1955.

    Article  PubMed  CAS  Google Scholar 

  13. Matsuda M, Nagumo S, Kayama H, et al: Occult thyroid cancer discovered by fine needle aspiration cytology of cervical lymph node: a report of three cases. Diagn Cytopathol 7:299–303, 1991.

    Article  PubMed  CAS  Google Scholar 

  14. Pelizzo MR, Piotto A, Rubello D, et al: High prevalence of occult papillary thyroid carcinoma in surgical series for benign thyroid diseases. Tumori 76:255–257, 1990.

    PubMed  CAS  Google Scholar 

  15. Penn I: Neoplastic complications of transplantation. Semin Respir Infect 8:233–239, 1993.

    PubMed  CAS  Google Scholar 

  16. Penn I:The effect of immunosuppression on pre-existing cancers. Transplantation. 55:742–747, 1993.

    Article  PubMed  CAS  Google Scholar 

  17. Sampson RJ, Key CR, Buncher CR, et al: Smallest forms of papillary carcinoma of the thyroid. Arch. Pathol. 91:334–339, 1971.

    PubMed  CAS  Google Scholar 

  18. Sasaki H, Sirakusa T, Suzuki K, et al: Occult papillary carcinoma of the thyroid presenting as a solitary pulmonary metastasis. Nippon Naibunpi Gakkai Zasshi 67:655–663, 1991.

    PubMed  CAS  Google Scholar 

  19. Stio F, Battisti G, Felisci A, et al: Thyroid cancer and its incidence in nodular thyroid diseases: our experience. G Chir 11:487–490, 1990.

    PubMed  CAS  Google Scholar 

  20. Torre G, Borgonovo G, Amato A, et al: Differentiated thyroid cancer: surgical treatment of 190 patients. Eur J Surg Oncol 22:276–281, 1996.

    Article  PubMed  CAS  Google Scholar 

  21. Woolner LB, Beahrs OH, Black BM, et al: Classification and prognosis of thyroid carcinoma. A study of 885 cases observed in a thirty year period. Am J Surg 102:354–387, 1981.

    Article  Google Scholar 

  22. Yamamoto Y, Maeda T, Izumi K, et al: Occult papillary carcinoma ot the thyroid. Cancer 65:1173–1179, 1990.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dept. of Transplantation and Surgery, Semmelweis University, Baross u. 23, H-1082, Budapest, Hungary

    Balázs Nemes, Hemangshu Podder, Jenô Járay, Péter Sótonyi, Katalin Földes & Ferenc Perner

  2. 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University, Budapest

    Attila Zalatnai & Zsuzsa Schaff

Authors
  1. Balázs Nemes
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  2. Attila Zalatnai
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  3. Hemangshu Podder
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  4. Jenô Járay
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  5. Péter Sótonyi
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  6. Zsuzsa Schaff
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  7. Katalin Földes
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  8. Ferenc Perner
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Correspondence to Balázs Nemes.

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Nemes, B., Zalatnai, A., Podder, H. et al. Papillary microcarcinoma of the thyroid gland in renal transplant patients. Pathol. Oncol. Res. 6, 72–75 (2000). https://doi.org/10.1007/BF03032662

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  • DOI: https://doi.org/10.1007/BF03032662

Keywords

  • papillary microcarcinoma
  • thyroid cancer
  • immunosuppression
  • renal transplantation