Among organ transplant recipients there is a world wide increase in the number of de novo tumors as well as a decrease in the time of the first appearance after the transplantation. Between 1973 and the 31th of August 1999 1709 cadaver renal allograft transplantations were perfomed in our Department. Four thyroid cancers were detected among the renal transplanted patients. Two of them proved to be papillary microcarcinomas. Although the elevated risk of thyroid cancers is well established in the literature papillary microcarcinomas have never been reported before in an immunosuppressed patient. Authors highlight that the thyroid gland should always be carefully checked in organ transplant recipients, since better survival might be achieve even in the immunosuppressed population. Metastatic tumor is relatively benign which is in correlation with the literature, but there has been little experience in organ transplanted patients so far.
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Auteliano F, Spagnoli LG, Santeusinaio G, et al: Occult carcinoma of the thyroid gland: an epidemiological study of autopsy material. Ann Ital Chir 61:141–146, 1990.
Brunner FP, Landais P, Seiwood NH: Malignancies after renal transplantation: the EDTA-ERA registry experience. European Dialysis and Transplantation Association-European Renal Association. Nephrol Dial Transplant 10:74–80, (suppl 1), 1995.
Buccianti G, Maisonneuve P, Ravasi B, et al: Cancer among patients on renal replacement therapy: a population based survey in Lombardi, Italy. Int J Cancer 66:591–593, 1996.
Carcangiu ML, Zampi G, Pupi A, et al: (1985) Papillary Carcinoma of the thyroid. A clinicopathologic Study of 241 Cases Treated at the Universitiy of Florence, Italy. Cancer 55:805–828, 1985.
Engel U, Kucharski A, Zornig C: Eingeschrankte Radikalitat bei differezierten Schilddrüsencarcinomen. Eine prospektive Studie an 107 Patienten. Chirurg 65:1095–1098, 1994.
Ésik O, Szentirmay Z, Tusnády G, et al: Malignus pajzsmirigytumorok Magyarországon:morbiditás és mortalités (Malignant thyroid tumors in Hungary:morbidity and mortality) Orv Hetil 137:905–911, 1996.
Fahey TJ 3rd, Reeve TS, Delbridge L: Increasing incidence and changing presentation of thyroid cancer over a 30 year period. Br J Surg 82:518–20, 1995.
Franceschi S, La Vecchia C: Thyroid cancer. Cancer Surv 19-20:393–422, 1994.
Hazard JB. Small papillary carcinoma of the thyroid: A study with special reference to so-called non-encapsulated sclerosing tumor. Lab Invest 8:86–97, 1960.
Hedinger C: Histological typing of thyroid tumors (2nd edition) Springer-Verlag, Berlin. Heidelberg, New York, London, Paris, Tokyo, 1988.
Hefer T, Joachims HZ, Eitan A, et al: Are the morphology of papillary thyroid carcinoma and the tumor’s behavior correlated? J Laryngol Otol 110:704–705, 1996.
Klinck GH, Winship T: Occult sclerosing carcinoma of the thyroid. Cancer 8:701–766, 1955.
Matsuda M, Nagumo S, Kayama H, et al: Occult thyroid cancer discovered by fine needle aspiration cytology of cervical lymph node: a report of three cases. Diagn Cytopathol 7:299–303, 1991.
Pelizzo MR, Piotto A, Rubello D, et al: High prevalence of occult papillary thyroid carcinoma in surgical series for benign thyroid diseases. Tumori 76:255–257, 1990.
Penn I: Neoplastic complications of transplantation. Semin Respir Infect 8:233–239, 1993.
Penn I:The effect of immunosuppression on pre-existing cancers. Transplantation. 55:742–747, 1993.
Sampson RJ, Key CR, Buncher CR, et al: Smallest forms of papillary carcinoma of the thyroid. Arch. Pathol. 91:334–339, 1971.
Sasaki H, Sirakusa T, Suzuki K, et al: Occult papillary carcinoma of the thyroid presenting as a solitary pulmonary metastasis. Nippon Naibunpi Gakkai Zasshi 67:655–663, 1991.
Stio F, Battisti G, Felisci A, et al: Thyroid cancer and its incidence in nodular thyroid diseases: our experience. G Chir 11:487–490, 1990.
Torre G, Borgonovo G, Amato A, et al: Differentiated thyroid cancer: surgical treatment of 190 patients. Eur J Surg Oncol 22:276–281, 1996.
Woolner LB, Beahrs OH, Black BM, et al: Classification and prognosis of thyroid carcinoma. A study of 885 cases observed in a thirty year period. Am J Surg 102:354–387, 1981.
Yamamoto Y, Maeda T, Izumi K, et al: Occult papillary carcinoma ot the thyroid. Cancer 65:1173–1179, 1990.
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Nemes, B., Zalatnai, A., Podder, H. et al. Papillary microcarcinoma of the thyroid gland in renal transplant patients. Pathol. Oncol. Res. 6, 72–75 (2000). https://doi.org/10.1007/BF03032662
- papillary microcarcinoma
- thyroid cancer
- renal transplantation