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Relationship between apoptosis regulator proteins (bcl-2 and p53) and Gleason score in prostate cancer

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Pathology Oncology Research

Abstract

Cellular proliferation programmed cell death (apoptosis) are associated with tumor growth in general, and prostate cancer growth in particular. The aim of this study was to examine the expression of the apoptosis regulating genes bcl-2 and p53 and Gleason score in core needle biopsy specimens of prostate cancer using immunohistochemistry. We studied bcl-2 and p53 expression in 12 cases of low grade (Gleason score 2–5), 12 cases of intermediate grade (Gleason score 6–7) and 8 cases of high grade (Gleason score 8–10) prostate cancer. Overexpression of bcl-2 was noted in 3 of 32 patients (9.32%). One of them was high grade; others were intermediate grades. Expression of p53 was observed in 3 of low grades; others were high grade. The statistical analysis of present data suggest that there is no significant relation between p53 and bcl-2 expression and Gleason score in prostate cancer.

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References

  1. Bauer JJ, Sesterhenn IA, Mostofi FK, et al; Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer. J Urol 156:1511–1516, 1996.

    Article  PubMed  CAS  Google Scholar 

  2. Boring CC, Squires T; Cancer statistics 1994. CA Cancer J Clin 44:7, 1994.

    Article  PubMed  CAS  Google Scholar 

  3. Bubendorf L, Sauter G, Moch H, et al; Prognostic significance of bcl-2 in clinically localized prostate cancer. Am J Pathol 148:1557, 1996.

    PubMed  CAS  Google Scholar 

  4. Cheng L, Leibovich BC, Bergstralh EJ, et al; P53 Alteration in regional lymph node metastases from prostate carcinoma. Cancer 85:2455–2459, 1999.

    Article  PubMed  CAS  Google Scholar 

  5. Cheng L, Sebo JT, Pisansky T, et al; P53 Protein Overexpression Is Associated with Increased Cell Proliferation in Patients with Locally Recurrent Prostate Carcinoma after Radiation Therapy. Cancer 85:1293–1299, 1999.

    Article  PubMed  CAS  Google Scholar 

  6. Fox SB, Persad RA, Royds J, et al; p53 and c-myc expression in stage A1 prostatic adenocarcinoma: Useful prognostic determinants? J Urol 150:490–494, 1993.

    PubMed  CAS  Google Scholar 

  7. Grignon DJ, Hammond EH; Collage of American pathologists conferance XXVI on clinical relevance of prognostic markers in solid tumors: Report of prostate cancer working group. Arch Pathol Lab Med 119:1122–1126, 1995.

    PubMed  CAS  Google Scholar 

  8. Grossfeld GD, Olumi AF, Connolly JA, et al; Locally recurrent prostate tumors following either radiation therapy or radical prostatectomy have changes in Ki-67 labelling index, p53 and bcl-2 immunoreactivity. J Urology 159:1437–1443, 1998.

    Article  CAS  Google Scholar 

  9. Hockenbery D, Nunez G, Milliam C, et al; Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334, 1990.

    Article  PubMed  CAS  Google Scholar 

  10. Issacs JT; Molecular markers for prostate cancer metastasis: Devoloping diagnostic methods for predicting the aggressiveness of prostate cancer. Am J Pathol 150:1511–1521, 1997.

    Google Scholar 

  11. Kallakury BV, Figge J, Ross JS, et al; Association of p53 immunoreactivity with high Gleason tumor grade in prostatic adenocarcinoma. Human Pathol 25:92, 1994.

    Article  CAS  Google Scholar 

  12. Levine AJ; P53, the cellular gatekeeper for growth and division. Cell88:323, 1997.

    Article  PubMed  CAS  Google Scholar 

  13. Masuda M, Takano Y, Iki M, et al; Prognostic Significance of Ki-67, p53 and bcl-2 expression in prostate cancer patients with lymph node metastases: A retrospective immunohistochemical analysis. Pathol Int:48:41–46, 1998.

    Article  PubMed  CAS  Google Scholar 

  14. Matsushima H, Kitamura T, Goto T, et al; Combined anaysis with bcl-2 and p53 immunostaining predicts poorer prognosis in prostatic carcinoma. J Urology 158:2278–2283, 1997.

    Article  CAS  Google Scholar 

  15. Prendergest NJ, Atkins MR, Schatte EC, et al; p53 immunohistochemical and genetic alterations are associated at high incidence with post-irradiated locally persistent prostate carcinoma. J Urol 155:1685–92, 1996.

    Article  Google Scholar 

  16. Piris MA, Pezzella F, Martinez-Montero JC, et al; p53 and bcl-2 expression in high grade B-cell lymphomas. Br J Cancer, 69:337, 1994.

    PubMed  CAS  Google Scholar 

  17. Shurbaji MS, Kalbfleisch JH, Thurmond S; Immunohistochemical detection of p53 protein as a prognostic indicator in prostate cancer. Human Path 26:106–109, 1995.

    Article  CAS  Google Scholar 

  18. Soini Y, Paakko P; Extent of Apoptosis in Relation to p53 and bcl-2 Expression in Germ Cell Tumors. Hum Pathol 27:1221–1226, 1996.

    Article  PubMed  CAS  Google Scholar 

  19. Von Eschenbach AC; The biologic dilemma of early carcinoma of prostate. Cancer 78:326–329, 1996.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Akdeniz University, The Faculty of Medicine, Antalya, Turkey

    Semra Karaburun Paker, Bahar Kilicarslan, Akif M. C. Ýftcýoglu, Sevim Oztekin & Figen C. Sargin

  2. Department of Urology, Akdeniz University, The Faculty of Medicine, Antalya, Turkey

    Tibet Erdogru & Mehmet Baykara

Authors
  1. Semra Karaburun Paker
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  2. Bahar Kilicarslan
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  3. Akif M. C. Ýftcýoglu
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  4. Sevim Oztekin
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  5. Figen C. Sargin
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  6. Tibet Erdogru
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  7. Mehmet Baykara
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Correspondence to Bahar Kilicarslan.

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Paker, S.K., Kilicarslan, B., Ýftcýoglu, A.M.C. et al. Relationship between apoptosis regulator proteins (bcl-2 and p53) and Gleason score in prostate cancer. Pathol. Oncol. Res. 7, 209–212 (2001). https://doi.org/10.1007/BF03032351

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  • DOI: https://doi.org/10.1007/BF03032351

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