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Calcium channel blocker prevents stress-induced activation of renin and aldosterone in conscious pig

Cardiovascular Drugs and Therapy volume 5, Article number: 643 (1991) Cite this article

Summary

A considerable amount of data suggest the involvement of calcium-mediated processes in the activation of the renin-angiotensin-aldosterone (RAA) cascade. To investigate the effect of calcium-channel inhibition on the RAA system, we studied 21 conscious pigs. Blood renin and aldosterone levels increased by subjecting animals to 24 hours of immobilization stress. Renin and aldosterone levels were repeatedly measured by radio-immunoassay in blood samples taken periodically over 24 hours from a chronically implanted arterial cannula. Pretreatment of the animals (N = 11) with nisoldipine, 2 × 20 mg p.o. daily for 2 days before and on the day of immobilization, transiently attenuated the stress-induced increase of plasma renin activity and completely prevented the rise of aldosterone, as compared to nontreated controls (N = 10). The finding that nisoldipine suppresses RAA activation induced by a nonpharmacologic stimulus in the conscious intact animal may have clinical implications.

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Affiliations

  1. Department of Cardiology. Postgraduate Medical School, Institute of Animal Physiology and Medical Research Centre of the Polish Academy of Sciences, Warsaw, Poland

    Leszek Ceremuzyński, Jadwiga Kloś, Bernard Barcikowski & Krystyna Herbaczyńska-Cedro

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  1. Leszek Ceremuzyński
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  2. Jadwiga Kloś
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  3. Bernard Barcikowski
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  4. Krystyna Herbaczyńska-Cedro
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Ceremuzyński, L., Kloś, J., Barcikowski, B. et al. Calcium channel blocker prevents stress-induced activation of renin and aldosterone in conscious pig. Cardiovasc Drug Ther 5, 643 (1991). https://doi.org/10.1007/BF03029733

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  • DOI: https://doi.org/10.1007/BF03029733

Key Words

  • renin
  • aldosterone
  • calcium channel blockers
  • stress