Summary
Hemorheologic parameters were measured in cerebrovascular patients with a history of stroke or recurrent ischemic attacks in a quiescent phase of the disease. All patients were submitted to aortic arch angiography and then classified according to the presence or absence of detectable arterial lesions. In comparison with a group of control subjects, cerebrovascular patients had significantly elevated levels of blood and plasma viscosity, fibrinogen, factors VIII:C and VIIIR:Ag and lowered values of erythrocyte filtration. Blood viscosity was increased and erythrocyte filtration reduced only in male patients. Elderly patients had higher blood viscosity and fibrinogen levels, and those with a history of stroke also showed the highest hematocrit and plasma viscosity values. Patients with a stroke history compared with those affected by remittent ischemic attacks, and patients with positive in comparison with those with negative angiograms were characterized only by higher fibrinogen (and sometimes factor VIII) levels, but not by other differences in hemorheologic values. It is concluded that changes in hemorheologic values consistent with hyperviscosity are a feature of cerebrovascular patients also in the quiescent phase of the disease and not only as a result of acute ischemic attacks. These changes are however most frequent in males and in elderly subjects, while they seem to be almost evenly distributed in patients with or without evidence of arterial disease.
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References
Bloom A. L.: The biosynthesis of factor VIII. In:Rizza C. R. (Ed.): Congenital coagulation disorders. W. B. Saunders Co., Philadelphia, 1979; vol. 8, p. 53.
Bloom A. L., Gjddings J. C., Wilks C. J.: Factor VIII in the vascular intima: possible importance in haemostasis and thrombosis — Nature (New Biol.)241, 217, 1973.
Boisseau M. R., Lorient M. F., Bricaud H., Doutremepuich Ch., Manuau J. P.: Réduction de la filtrabilité érythrocytaire au cours des accidents vasculaires cérébraux. In: IV Séminaire du Groupe de travail sur la filtration érythrocytaire. Laboratories Hoechst, Puteaux, 1979; p. 273.
Brown M. M., Marshall J.: Effect of plasma-exchange on blood viscosity and cerebral blood flow — Brit. med. J.284, 1733, 1932.
Chievitz E., Thiede T.: Complications and causes of death in polycythaemia vera — Acta med. scand.172, 513, 1962.
Clauss A.: Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens — Acta haematol. (Basel)17, 237, 1957.
Di Perri T.: Haemorheological changes in vasculopathic patients as a consequence of the ischemia. In: 2nd Europ. Conf. on Clinical Haemorheology, London, 1981. (Abstract no. 153).
Grotta J., Ackerman R., Correia J., Fallick G., Chang J.: Whole blood viscosity parameters and cerebral blood flow — Stroke13, 296, 1982.
Guerrini M.,Rossi C.,Acciavatti A.,Pieragalli D.,Forconi S.,Di Perri T.: Haemorheological aspects of stroke. In: 2nd Europ. Conf. on Clinical Haemorheology, London, 1981. (Abstract no. 116).
Harrison M. J. G., Pollock S., Kendall B. E., Marshall J.: Effect of haemtocrit on carotid stenosis and cerebral infarction — Lancetii, 114, 1981.
Henriksen L., Paulson O. B., Smith R. J.: Cerebral blood flow following normovolemic hemodilution in patients with high hematocrit — Ann. Neurol.9, 454, 1981.
Humphrey P. R. D., Du Boulay G. H., Marshall J., Pearson T. C., Ross Russell R. W., Symon L., Wetherley-Mein G., Zilkha E.: Cerebral blood flow and viscosity in relative polycythaemia — Lancetii, 873, 1979.
Humphrey P. R. D., Du Boulay G. H., Marshall J., Pearson T. C., Ross Russell R. W., Slater N. G., Symon L., Wetherley-Mein G., Zilkha E.: Viscosity, cerebral blood flow and haematocrit in patients with paraproteinaemia — Acta neurol. scand.61, 201, 1980.
Kannel W. B., Gordon T., Wolf P. A., McNamara P.: Hemoglobin and the risk of cerebral infarction: the Framingham study — Stroke3, 409, 1972.
Lorient M. F., Boisseau M. R., Manuau J. P., Bricaud H.: Troubles de la filtrabilité des hématies au cours des accidents vasculaires cérébraux. Corrélation avec les facteurs de risque chez 80 malades à la phase aiguë — J. Malad. vasc. (Paris)4, 251, 1979.
Ott E. O., Ladurner G., Lechner H.: Relationship between disturbed rheological properties and cerebral hemodynamics in recent cerebral infarction — Progr. biochem. Pharmacol.13, 349, 1977.
Ott E. O., Lechner H., Aranibar A.: High blood viscosity syndrome in cerebral infarction — Stroke5, 330, 1974.
Palareti G., Poggi M., Limoni P., Andreoli A., Tricarico M. G., Coccheri S.: Changes in the rheologic properties of blood in acute cerebrovascular disease: effects of treatment with l-eburnamonine — Int. Angiol.2, 179 1983.
Pearson T. C., Wetherley-Mein G.: Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia — Lancetii, 1219, 1978.
Pollock S., Tsitsopoulos P., Harrison M. J. G.: The effect of haematocrit on cerebral perfusion and clinical status following carotid occlusion in the gerbil — Stroke13, 167, 1982.
Reid H. L., Barnes A. J., Lock P. J., Dormandy J. A., Dormandy T. L.: A simple method for measuring erythrocyte deformability — J. clin. Pathol.29, 855, 1976.
Sakuta S.: Blood filterability in cerebrovascular disorders, with special reference to erythrocyte deformability and ATP content — Stroke12, 824, 1981.
Thomas D. J.: The influence of blood viscosity on cerebral blood flow and symptoms. In:Greenhalgh R. M.,Rose F. C. (Eds): Progress in stroke research. Pitman Med., Tunbridge Wells, 1979; vol. 1, p. 47.
Thomas D. J.: Whole blood viscosity and cerebral blood flow — Stroke13, 285, 1982.
Thomas D. J., Du Boulay G. H., Marshall J., Pearson T. C., Ross Russell R. W., Symon L., Wetherley-Mein G., Zilkha E.: Cerebral blood flow in polycythaemia — Lancetii, 161, 1977.
Tohgi H., Yamanouchi H., Murakami M., Kameyama M.: Importance of the hematocrit as a risk factor in cerebral infarction — Stroke9, 369, 1978.
Wood J. H., Fleischer A. S.: Observations during hypervolemic hemodilution of patients with acute focal cerebral ischemia — J. Amer. med. Ass.248, 2999, 1982.
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Coccheri, S., Palareti, G., Poggi, M. et al. Hemorheologic changes in patients with a history of stroke or cerebral remittent ischemic attacks. La Ricerca Clin. Lab. 15, 39–46 (1985). https://doi.org/10.1007/BF03029160
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DOI: https://doi.org/10.1007/BF03029160