Summary
Anti-idiotypic (anti-Id) antibodies are directed against antigenic determinants expressed by the antigen-binding region of the immunoglobulin molecules. Their interaction with antigen receptors on immune cells modulates the immune response. In man auto-anti-Id antibodies have been demonstrated. These antibodies not only participate in the regulation of the immune response, but can result in disease as in the case of acquired angioedema with B cell malignancy and possibly in autoimmune diseases. Anti-Id antibodies may be useful tools in cancer immunotherapy and in the production of vaccines.
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References
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Supported by the USPHS grant AM-31925-01, AI-21163, AI-20373-01 and a grant from the National Foundation. Raif S. Geha is the recipient of an Allergic Diseases Academic Award K07 AI-0440-02.
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Geha, R.S. Idiotypic-antiidiotypic interactions in man. La Ricerca Clin. Lab. 15, 1–8 (1985). https://doi.org/10.1007/BF03029155
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DOI: https://doi.org/10.1007/BF03029155