Summary
In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-γ inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined toin vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mcie.
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This work was supported by grants from theConsiglio Nazionale delle Ricerche (CNR), Roma, Italy,Progetto Finalizzato ‘Oncologia’ (contract no. 85.02161.44) and from theAssociazione Italiana per la Ricerca sul Cancro (AIRC).
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Landolfo, S., Cofano, F., Giovarelli, M. et al. Interferon-γ plays a crucial role in T lymphocyte reaction against alloantigens. La Ricerca in Clin. Lab. 15, 307–314 (1985). https://doi.org/10.1007/BF03029144
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DOI: https://doi.org/10.1007/BF03029144