The Journal of Nutrition, Health & Aging

, Volume 12, Issue 10, pp 690–695 | Cite as

Age, race and season predict vitamin D status in African American and white octogenarians and centenarians

  • M. A. Johnson
  • A. Davey
  • S. Park
  • D. B. Hausman
  • L. W. Poon
  • The Georgia Centenarian Study


Objective: Poor vitamin D status has been associated with osteoporosis, falls, cardiovascular diseases, cancer, autoimmune diseases, pain, nursing home placement, and other age-related conditions, but little is known about the prevalence and predictors of vitamin D status in those aged 80 and older. Thus, this study tested the hypothesis that vitamin D status would be 1) poorer in a population-based multi-ethnic sample of centenarians as compared with octogenarians and 2) predicted by specific dietary, demographic or environmental factors.Design: Cross-sectional population-based analyses.Setting: Northern Georgia in the United States.Participants: Men and women aged 80 to 89 (octogenarians, n=80) and 98 and older (centenarians, n=237).Measurements: Regression analyses were used to examine the associations of serum 25-hydroxyvitamin D [25(OH)D] with age, gender, race, living arrangements, dairy food intake, supplement intake, and season.Results: The prevalence of vitamin D insufficiency [25(OH)D<50 nmol/L] was higher in centenarians than in octogenarians (p<0.02). In logistic regression analyses, the risk of being vitamin D insufficient was significantly increased by being a centenarian vs. octogenarian (p<0.005) and by being African American vs. white (p<0.001) and decreased by taking a supplement with vitamin D (p<0.001) or by having vitamin D status measured in the summer or fall (each p<0.05), compared with spring.Conclusions: Centenarians and octogenarians are at high risk for vitamin D insufficiency for many of the same reasons identified in younger populations. Given the numerous potential adverse consequences of poor vitamin D status, efforts are needed to ensure vitamin D adequacy in these older adults.

Key words

Centenarians elderly 25(OH)vitamin D nutrition risk factors nutrition supplements 


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  1. 1.
    Hetzel L, Smith A. The 65 years and over population: 2000. Census 2000 Brief. US Census Bureau. (2005). (accessed 7 November 2006)Google Scholar
  2. 2.
    Chan YC, Suzuki M, Yamamoto S. Dietary, anthropometric, hematological and biochemical assessment of the nutritional status of centenarians and elderly people in Okinawa, Japan. J Am Coll Nutr 1997;16:229–35.PubMedGoogle Scholar
  3. 3.
    Basile G, Gangemi S, Lo Balbo C, Mento A, Nicita-Mauro C, Crisafulli G, Merendino RA, Ientile R, Nicita-Mauro V. Correlation between serum retinol and alpha-tocopherol levels in centenarians. J Nutr Sci Vitaminol (Tokyo) 2003;49:287–8.Google Scholar
  4. 4.
    Pinzani P, Petruzzi E, Orlando C, Poggesi M, Monami M, Pazzagli M, Masotti G. Serum total antioxidant capacity, DHEAS and IGF-I in healthy centenarian subjects. J Endocrinol Invest 2002;25(10 Suppl):83–4.PubMedGoogle Scholar
  5. 5.
    Mecocci P, Polidori MC, Troiano L, Cherubini A, Cecchetti R, Pini G, Straatman M, Monti D, Stahl W, et al. Plasma antioxidants and longevity: a study on healthy centenarians. Free Radic Biol Med 2000;28:1243–8. Erratum in: Free Radic Biol Med 2000;29:486.PubMedCrossRefGoogle Scholar
  6. 6.
    Arakawa M, Miyake Y, Taira K. Hypertension and stroke in centenarians, Okinawa, Japan. Cerebrovascular Diseases 2005;20:233–8.PubMedCrossRefGoogle Scholar
  7. 7.
    Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, Barzilai N. Clinical phenotype of families with longevity. J Am Geriatr Soc 2000;52:274–7.CrossRefGoogle Scholar
  8. 8.
    Evert J, Lawler E, Bogan H. Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci 2003;58:232–7.PubMedGoogle Scholar
  9. 9.
    Terry DF, Wilcox MA, McCormick, MA, Pennington JY, Schoenhofen EA, Andersen SL, Perls TT. Lower all-cause, cardiovascular, and cancer mortality in centenarians’ offspring. J Am Geriatr Soc 2004:2074–6.Google Scholar
  10. 10.
    Passeri G, Pini G, Troiano L, Vescovini R, Sansoni P, Passeri M, Gueresi P, Delsignore R, Pedrazzoni M, et al. Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinol Metab 2003;88:5109–15.PubMedCrossRefGoogle Scholar
  11. 11.
    Passeri G, Vescovini R, Sansori P, Galli C, Franceschi C, Passeri M for the Italian Multicentric Study on Centenarians (IMUSCE). Calcium metabolism and vitamin D in the extreme longevity. Exp Gerontol 2008;43:79–87.PubMedCrossRefGoogle Scholar
  12. 12.
    Holick, M. F. The vitamin D epidemic and its health consequences. J Nutr 2005;135:2739S-48S.PubMedGoogle Scholar
  13. 13.
    Dawson-Hughes B. Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women. Am J Clin Nutr 2004:80(6 Suppl):1763S-6S.PubMedGoogle Scholar
  14. 14.
    Johnson MA, Fischer JG, Park S. Vitamin D deficiency and insufficiency in the Georgia Older Americans Nutrition Program. J Nutr Elderly (in press, accepted July 9, 2007).Google Scholar
  15. 15.
    Park S, Johnson MA. Living in low-latitude regions in the United States does not prevent poor vitamin D status. Nutr Rev 2005;63:203–9.PubMedCrossRefGoogle Scholar
  16. 16.
    Heaney RP. The vitamin D requirement in health and disease. J Steroid Biochem Mol Biol 2005;97:13–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Houston DK, Cesari M, Ferrucci L, Cherubini A, Maggio D, Bartali B, Johnson MA, Schwartz GG, Kritchevsky SB. Association between vitamin D status and physical performance: The InCHIANTI Study. J Gerontol A Biol Sci Med Sci 2007; 62:440–6.PubMedGoogle Scholar
  18. 18.
    Johnson MA, Kimlin M. Vitamin D, aging, and the 2005 Dietary Guidelines for Americans. Nutr Rev 2006;64;410–21.PubMedCrossRefGoogle Scholar
  19. 19.
    Brock K, Wilkinson M, Cook R, Lee S, Bermingham M. Associations with vitamin D deficiency in “at risk” Australians. J Steroid Biochem Mol Biol 2004;89–90;581–8.PubMedCrossRefGoogle Scholar
  20. 20.
    O’Dowd KJ, Clemens TL, Kelsey JL, Lindsay R. Exogenous calciferol (vitamin D) and vitamin D endocrine status among elderly nursing home residents in the New York City area. J Am Geriatr Soc 1993;41;414–21.PubMedGoogle Scholar
  21. 21.
    Gloth FM 3rd, Gundberg CM, Hollis BW, Haddad JG Jr, Tobin JD. Vitamin D deficiency in homebound elderly persons. JAMA 1995;274:1683–6.PubMedCrossRefGoogle Scholar
  22. 22.
    Stein MS, Flicker L, Scherer SC, Paton LM, O’Brien ML, Walton SC, Chick P, Di Carlantonio M, Zajac JD, et al. Relationships with serum parathyroid hormone in old institutionalized subjects. Clin Endocrinol (Oxf) 2001;54:583–92.CrossRefGoogle Scholar
  23. 23.
    U.S. Department of Health and Human Services and U.S. Department of Agriculture. (2005). Dietary Guidelines for Americans. Internet: (accessed 7 November 2006).Google Scholar
  24. 24.
    Poon LW, Jazwinski SM, Green RC, Woodard JL, Martin P, Rodgers WL, Johnson MA, Hausman DB, Arnold J, et al. Methodological considerations in studying centenarians: lessons learned from the Georgia centenarian studies. Ann Rev Gerontology and Geriatrics 2007;27:213–264.Google Scholar
  25. 25.
    Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone 2002;30:771–7.PubMedCrossRefGoogle Scholar
  26. 26.
    Hollis BW. Comparison of commercially available (125)I-based RIA methods for the determination of circulating 12-hydroxyvitamin D. Clin Chem 2000;46:1657–1661.PubMedGoogle Scholar
  27. 27.
    Lips, P. Which circulating level of 25-hydroxyvitamin D is appropriate? J Steroid Biochem Mol Biol 2004;89–90:611–4.PubMedCrossRefGoogle Scholar
  28. 28.
    Guigoz Y, Vellas B, Garry PJ. Assessing the nutritional status of the elderly: the Mini-Nutritional Assessment as part of the geriatric evaluation. Nutr Rev. 1996;54:59–65.CrossRefGoogle Scholar
  29. 29.
    Nesby-O’Dell S, Scanlon KS, Cogswell ME, Gillespie C, Hollis BW, Looker AC, Allen C, Doughertly C, Gunter EW, et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr 2002;76:187–92.PubMedGoogle Scholar
  30. 30.
    Visser M, Deeg DJH, Puts MTE, Seidell JC, Lips P. Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admissions. Am J Clin Nutr 1996;84:616–22.Google Scholar
  31. 31.
    Andersen-Ranberg K, Schroll M, Jeune B. Healthy centenarians do not exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenarians. J Am Geriatr Soc. 2001;49: 900–8.PubMedCrossRefGoogle Scholar
  32. 32.
    Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, Staehelin HB, Bazemore MG, Zee Ry, Wong JB. Effect of Vitamin D on falls: a meta-analysis. JAMA 2004;291:1999–2006.PubMedCrossRefGoogle Scholar
  33. 33.
    Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005;293:2257–64.PubMedCrossRefGoogle Scholar
  34. 34.
    Mariani E, Ravaglia G, Forti P, Meneghetti A, Tarozzi, A, Maioli F, Boschi F, Pratelli L, Pizzoferrato A, et al. Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians. Clin Exp Immunol 1999;116:19–27. Erratum in: Clin Exp Immunol 1999;117,206.PubMedCrossRefGoogle Scholar
  35. 35.
    Sato Y, Iwamoto J, Kanoko T, Satoh K. Amelioration of ostseoporosis and hypovitaminosis D by sunlight exposure in hospitalized, elderly women with Alzheimer’s disease: a randomized controlled trial. J Bone Miner Res 2005;20:1327–33.PubMedCrossRefGoogle Scholar
  36. 36.
    Harris SS, Soteriades E, Coolidge JA, Mudgal S, Dawson-Hughes B. Vitamin D insufficiency and hyperparathyroidism in a low income, multiracial, elderly population. J Clin Endocrinol Metab 2000;85:4125–30.PubMedCrossRefGoogle Scholar
  37. 37.
    Jacques PF, Felson DT, Tucker KL, Mahnken B, Wilson PW, Rosenberg IH, Rush D. Plasma 25-hydroxyvitamin D and its determinants in an elderly population sample. Am J Clin Nutr 1997;66:929–36.PubMedGoogle Scholar
  38. 38.
    Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999;69:842–56.PubMedGoogle Scholar
  39. 39.
    Fischer JG, Johnson MA, Poon LW, Martin P. Dairy product intake of the oldest old. J Am Diet Assoc 1995;95: 918–921.PubMedCrossRefGoogle Scholar
  40. 40.
    Kinyamu HK, Gallagher JC, Balhorn KE, Petranick KM, Rafferty KA. Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes. Am J Clin Nutr 1997;65:790–7.PubMedGoogle Scholar
  41. 41.
    Johnson MA, Davey A, Hausman DB, Park S, Poon LW. Dietary differences between centenarians residing in communities and in skilled nursing facilities: the Georgia Centenarian Study. Age 2006;28:333–41.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag and Serdi Éditions 2008

Authors and Affiliations

  • M. A. Johnson
    • 1
  • A. Davey
    • 2
  • S. Park
    • 1
  • D. B. Hausman
    • 1
  • L. W. Poon
    • 3
  • The Georgia Centenarian Study
  1. 1.Department of Foods and NutritionThe University of GeorgiaAthens
  2. 2.College of Health ProfessionsTemple UniversityPhiladelphiaUSA
  3. 3.Institute of GerontologyUniversity of GeorgiaAthensUSA

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