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Comparison of extraarticular leakage values of radiopharmaceuticals used for radionuclide synovectomy

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Abstract

Objectives

Radionuclide synovectomy is a reliable therapy in patients with chronic synovitis. However, radiation doses delivered to non-target organ systems due to leakage of radioactive material from the articular cavity are an important disadvantage of this procedure. In this study we compared extraarticular leakage values of the 3 commonly used radiopharmaceuticals;90Y-citrate,90Y-silicate and186Re-sulfide colloid.

Materials and Methods

Thirty-five patients with persistent synovitis were enrolled in the study. Twenty-two hemophilic, 8 rheumatoid arthritis and 5 patients with pigmented villonodular synovitis were studied.90Y labeled silicate and citrate were used for knee joints and186Re-sulfide for intermediate sized joints. Radiocolloid leakage values were evaluated using a gamma camera with 20% window centered over the bremsstrahlung photopeak of90Y and a respective window over the 137 keV photopeak of186Re. Regions of interest were drawn over the injection site, the regional lymph nodes and the background areas. Leakage of radiocolloid was calculated by dividing the counts/pixel in the regional lymph node area to the counts/pixel in the injection site.

Results

No visible leakage was observed. The median leakage values calculated for90Y-citrate,90Y-silicate and186Re-sulfide were found as 1.9%, 2.4% and 2.7%, respectively. The difference between the variability of leakage values was not statistically significant (p > 0.05).Conclusion: There was no significant difference in terms of extraarticular leakage between90Y-citrate,90Y-silicate and186Re-sulfide radiocolloids.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Hacettepe University, Faculty of Medicine, 06100, Sihhiye, Ankara, Turkey

    Gonca Kara Gedik & Ömer Uğur

  2. Department of Orthopedics and Traumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey

    Bülent Atilla & Murat Pekmezci

  3. Department of Nuclear Medicine, Atatiirk University, Faculty of Medicine, Erzurum, Turkey

    Mustafa Yildirim, Bedri Seven & Erhan VaroĞlu

Authors
  1. Gonca Kara Gedik
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  2. Ömer Uğur
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  3. Bülent Atilla
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  4. Murat Pekmezci
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  5. Mustafa Yildirim
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  6. Bedri Seven
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  7. Erhan VaroĞlu
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Correspondence to Gonca Kara Gedik.

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Gedik, G.K., Uğur, Ö., Atilla, B. et al. Comparison of extraarticular leakage values of radiopharmaceuticals used for radionuclide synovectomy. Ann Nucl Med 20, 183–188 (2006). https://doi.org/10.1007/BF03027428

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  • DOI: https://doi.org/10.1007/BF03027428

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