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Visualization of gallbladder with In-111 labeled octreotide in post prandial state

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Abstract

Somatostatin receptor scintigraphy is widely used in the management of neuroendocrine tumors. Somatostatin receptors are present in both neoplastic and normal tissues, which may lead to misinterpretation of the scans. Here, a patient with lung carcinoid imaged with In- 111 octreotide is presented. Imaging was performed 4 and 24 hours after an intravenous injection of 185 MBq In-111 octreotide in the post prandial state. Whole body and SPECT images showed accumulation of radioactivity in the gallbladder. Imaging was repeated after fatty meal ingestion to differentiate abnormal activity and physiological uptake in the gallbladder. The abdominal SPECT studies at 28 hours revealed no uptake in the gallbladder, and the scintigraphic study was reported as normal so further excessive diagnostic procedures were prevented. Gallbladder can be visualized on soma-tostatin receptor scintigraphy even in the post prandial state. Delayed images after fatty meal administration are important for differential diagnosis.

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References

  1. Shapiro B, Fig LM, Gross MD, Shulkin BL, Sisson JC. Neuroendocrine Tumors. In:Nuclear Oncology, Aktolun C, Tauxe WN (eds), Berlin Heildelberg; Springer-Verlag, 1999:3–31.

    Google Scholar 

  2. Gibril F, Reynolds JC, Chen CC, Fang Y, Gobel SU, Serrano J, et al. Specificity of somatostatin receptor scintig- raphy: A prospective study and effects of false-positive localizations on management in patients with gastrinomas.J Nucl Med 1999; 40: 539–553.

    PubMed  CAS  Google Scholar 

  3. Kwekkeboom DJ, De Jong M, Krenning EP. Somatostatin Receptor Scintigraphy. In:Diagnostic Nuclear Medicine, Sandler MP, Coleman RE, Patton JA, Wackers FJ, Gottschalk A (eds), Philadelphia; Lippincott Williams & Wilkins, 2003: 735–746.

    Google Scholar 

  4. Sakaki M, Hirokawa M, Sano T, Horiguchi H, Wakatsuki S, Ogata S. Gallbladder adenocarcinoma with florid neuroendocrine cell nests and extensive paneth cell metaplasia.Endocr Pathol 2000; 11 (4): 365–371.

    Article  PubMed  Google Scholar 

  5. Kuwabara H, Uda H. Small cell carcinoma of the gallbladder with intestinal metaplastic epithelium.Pathol Int 1998; 48: 303–306.

    Article  PubMed  CAS  Google Scholar 

  6. Kwekkeboom DJ, Krenning EP. Somatostatin Receptor Imaging in Oncology. In:Nuclear Oncology, Aktolun C, Tauxe WN (eds), Berlin Heildelberg; Springer-Verlag, 1999: 345–357.

    Google Scholar 

  7. Krausz Y, Shibley N, De Jong RBJ, Yaffe S, Glaser B. Gallbladder visualization with In-111 labeled octreotide.ClinNuclMed 1994; 19 (2): 133–135.

    CAS  Google Scholar 

  8. Krenning EP, Bakker WH, Kooij PP, et al. Somatostatin receptor scintigraphy with Indium 111-DTPA-D-Phe-l- Octreotide in man: metabolism, dosimetry and comparison with iodine-123-Tyr-3-octreotide.J Nucl Med 1992; 33: 652–658.

    PubMed  CAS  Google Scholar 

  9. Kipper MS, Krohn LD. Gallbladder visualization at twenty- four hours with octreotide scintigraphy. Potential false-positive finding.Clin Nucl Med 1997; 22: 253–254.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Gonca Kara Gedik.

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Gedik, G.K., Kiratli, P.O. & Erbas, B. Visualization of gallbladder with In-111 labeled octreotide in post prandial state. Ann Nucl Med 20, 557–560 (2006). https://doi.org/10.1007/BF03026821

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  • DOI: https://doi.org/10.1007/BF03026821

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