Summary and Conclusion
Effects of halothane-nitrous oxide and oxygen anaesthesia alone for 11/2 hours and of surgery on plasmaadh, serum osmolality, urine volume and urine osmolality were studied in 14 patients. The mean plasmaadh level after premedication with pentobarbitone, pethidine and atropine was 2.8 μu/ml, which was within normal limits (0.4–3.5 μu/ml). It increased significantly by as much as 2.7 times the control level after 11/2 hours of halothane anaesthesia. Surgical stress further increased it (7.5 times). Serum osmolality remained relatively stable.adh secretion appears to play a role on the decreased urine volume and elevated urine osmolality. The clinical application of the present study is also discussed.
Résumé
Nous avons étudié chez 14 malades anesthésiés à l'halothane, protoxyde d'azote et oxygène, les effets de l'anesthésie seule durant une heure et demie et les effets de la chirurgie sur le taux d'adh dans le plasma, sur l'osmolalité sérique, sur le volume urinaire, sur l'osmolalité de l'urine. Après la prémédication avec du pentobarbitone, de la pethidine et de l'atropine, le taux moyen d'adh dans le plasma était de 2.8 μu/ml, ce qui se range dans les limites de la normale (0.4–3.5 μu/ml). Après une heure et demie d'anesthésie à l'halothane, le taux a augmenté de 2.1 fois. L'agression chirurgicale a provoqué une élévation additionnelle (7.5 fois). L'osmolalité sérique est demeurée relativement stable. La sécrétion d'adh semble être un facteur participant à la diminution du volume d'urine et à l'élévation de l'osmolalité de l'urine. Nous avons également discuté l'application clinique de cette étude.
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Oyama, T., Sato, K. & Kimura, K. Plasma levels of antidiuretic hormone in man during halothane anaesthesia and surgery. Canad. Anaesth. Soc. J. 18, 614–620 (1971). https://doi.org/10.1007/BF03026181
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DOI: https://doi.org/10.1007/BF03026181