Summary
Deep sedation and a laissez faire attitude occurs in cats when Innovar is placed into the posterior hypothalamus, the centro-median thalamic nucleus and the ventropostero-lateral thalamic nucleus through precise stereotaxically implanted recording cannulae. This sedation persists in the presence of pin-prick stimulation as observed by the persistence of neocortical deactivation and hippocampal activation or seizures.
Following the application of Innovar into the mesencephalic reticular and pontine reticular formations, no persistent behavioural or electroencephalographic evidence of sedation was observed in the presence of pin-prick stimulation.
Résumé
Il se produit une sédation profonde et une attitude de “laisser faire” chez les chats lorsqu’on introduit de l’Innovar dans l’hypothalamus postérieur, dans le noyau thalamique centro-médian, et dans le noyau thalamique ventro-postéro-latéral, à l’aide de canules enregistreuses implantées avec précision par une technique stéréotaxique. Cette sédation persiste en présence d’une stimulation par piqure d’épingle comme on l’a observé par la persistance de déactivation néocorticale et d’activation ou attaque de l’hyppocampe.
A la suite d’application d’Innovar dans les formations réticulaires mésencéphaliques et dans les formations réticulaires protubérentielles, on n’a observé aucune évidence de sédation persistante ni dans la conduite générale ni dans l’électroencéphalographie, même après stimulation par piqure d’épingle.
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Yanagida, H., Yamamura, H. The site of action of innovar in the brain. Canad. Anaesth. Soc. J. 18, 552–557 (1971). https://doi.org/10.1007/BF03026017
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DOI: https://doi.org/10.1007/BF03026017