Article PDF
Avoid common mistakes on your manuscript.
References
Lewis, J. J.;Martin-Smith, M.;Muir, T. C.; &Ross, H. H. Steroidal monoquaternary ammonium salts with non-depolarizing neuromuscular blocking activity. J. Pharm. & Pharmacol.19: 502 (1967).
Baird, W. L. M. &Reid, A. M. The neuromuscular blocking properties of a new steroid compound, pancuronium bromide. Brit. J. Anaesth.,39: 775 (1967).
Buckett, W. R.;Marjoribanks, C. E. B.;Marwick, F. A.; &Morton, M. B. The pharmacology of pancuronium bromide (Org.NA97), a new potent steroidal neuromuscular blocking agent. Brit. J. Pharmac. Chemother.32: 671 (1968).
Crul, J. F. Studies on new steroid relaxants. Progress in Anaesthesiology, Amsterdam Excerpta Medica (1970).
Sellick, B. A. Pancuronium bromide: clinical experience of a new muscle relaxant. Progress in Anaesthesiology, Amsterdam Excerpta Medica (1970).
Bonta, I. L.;Goorissen, E. M.; &Derkx, F. H. Pharmacological interaction between pancuronium bromide and anaesthetics. Europ. J. Pharmacology,4: 83 (1968).
Smith, G.;Proctor, D. W. &Spence, A. A. A comparison of some cardiovascular effects of tubocurarine and pancuronium in dogs. Brit. J. Anaesth.,42: 923 (1970).
Loh, L. The cardiovascular effects of pancuronium bromide. Anaesthesia,25: 356 (1970).
Lund, I. &Stovner, J. Dose-response curves for tubocurarine alcuronium and pancuronium. Acta Anaesth. Scandinav.,14: Suppl. xxxvii, 238 (1970).
Wolfson, B. Minor laryngeal sequelae of endotracheal intubation. Brit. J. Anaesth.,30: 326 (1958).
Rex, M. A. E. Respiratory reflexes during intubation and cuff inflation in the dog. Proceedings of the Third Asian and Australasian Congress of Anaesthesiology, Australia. Butterworths (1970).
Thomas, E. T. The effect of d-tubocurarine chloride on the blood pressure of anaesthetized patients. Lancet,2: 772 (1957).
Foldes, F. F. The pharmacology of neuromuscular blocking agents in man. Clin. Pharmacol. & Therap.,1: 345 (1960).
Stojanov, E. Possibilities for clinical use of the new steroid neuromuscular blocker pancuronium bromide in anaesthesiological practice. Arzneimittel-Forschung,19: 1723 (1969).
Dobkin, A. B.;Heinrich, R. G.;Israel, J. S.;Levy, A. A.;Neville, J. F., Jr.; &Ounkasem, K. Clinical and laboratory evaluation of a new inhalation agent: Compound 347 (CHF2−O−CF2 CHF Cl). Anesthesiology,29: 275 (1968).
Dobkin, A. B.;Byles, P. H.;Ghanooni, S.; &Valbuena, D. A. Clinical and laboratory evaluation of a new inhalation anaesthetic, Compound 469 (Forane): CHF2t-O−CHCl CF3 (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether). Canad. Anaesth. Soc. J.,18: 264 (1971).
Foldes, F. F. Factors which alter the effects of muscle relaxants. Anesthesiology,20: 464 (1959).
Kemp, S. W. &Morton, H. J. V. The effect of atropine and neostigmine on the pulse rate of anaesthetised patients. Anaesthesia,17: 170 (1962).
Kjellberg, M. &Tammisto, T. Heart-rate changes after atropine and neostigmine given for the reversion of muscle paralysis. Acta Anaesth. Scandinav.,14: 203 (1970).
Kalow, W. The influence of pH on the ionization and biological activity of d-tubocurarine. J. Pharmacol. & Exp. Therap.,110: 433 (1954).
Cohen, E. N.;Hood, N.; &Canner, P. Blood pH and plasma levels of d-tubocararine. Anesthesiology,26: 6 (1965).
Walts, L. F. &Dillon, J. B. Duration of action of d-tubocurarine and Gallamine. Anaesthesiology,29: 499 (1968).
Griffith, H. R. &Johnson, G. E. The use of curare in general anesthesia. Anesthesiology,3: 418 (1942).
Additional information
From the Department of Anesthesiology, State University Hospital, State University of New York, Upstate Medical Center, Syracuse, New York, 13210, U.S.A.
This study was supported by a grant-in-aid from Dr. Henry A. Strade of Organon Inc., West Orange, New Jersey and from the Division of Research Facilities and Resources of the National Institutes of Health through Grantfr 00353. Robert Gelder,b.a., helped in the analysis of the data.
Rights and permissions
About this article
Cite this article
Dobkin, A.B., Evers, W., Ghanooni, S. et al. Pancuronium bromide (Pavulon®) evaluation of its clinical pharmacology. Canad. Anaesth. Soc. J. 18, 512–535 (1971). https://doi.org/10.1007/BF03026014
Issue Date:
DOI: https://doi.org/10.1007/BF03026014