Summary
Oxalic acid excretion was measured in nine patients receiving methoxyflurane and six patients receiving halothane. Oxalic acid excretion increased from 5 to 23 times in the immediate postoperative period in patients receiving methoxyflurane, whereas no increase was noted in those receiving halothane. Despite the striking increase in oxalic acid excretion, no alteration in renal function and no polyuric state developed. The renal failure that occasionally develops after methoxyflurane anaesthesia appears to be multifactorial in origin and a hyperoxaluric state may play a role in some instances.
Résumé
On a mesuré l’excrétion d’acide oxalique chez neuf malades anesthésiés au méthoxyflurane et six malades anesthésiés au fluothane. L’excrétion d’acide oxalique a autmenté de 5 à 23 fois durant la période post-opératoire chez les malades anesthésiés au méthoxyflurane alors que chez les autres on n’a noté aucune augmentation. Malgré cette augmentation frappante de l’excrétion d’acide oxalique, il ne se produisit pas de changement dans la fonction rénale ni de polyurie. Bien que l’insuffissance rénale qui se produit quelquefois après l’anesthésie au méthoxyflurane semple être dûe à plusieurs facteurs, il semble évident que la dose d’anesthésique administrée peut être un facteur crucial.
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Department of Medicine and Department of Anaesthesia, University of Alberta, Edmonton, Alberta.
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Silverberg, D.S., McIntyre, J.W.R., Ulan, R.A. et al. Oxalic acid excretion after methoxyflurane and halothane anaesthesia. Canad. Anaesth. Soc. J. 18, 496–504 (1971). https://doi.org/10.1007/BF03026012
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DOI: https://doi.org/10.1007/BF03026012