Abstract
The ability of human recombinant interleukin-6 (IL-6) to regulate the induction and cytotoxic function of lymphokine activated killer (LAK) cells from human fetal spleen was studied. The results showed that IL-6 alone was unably to induce fetal splenic mononuclear cells (FSMC) to develop functional LAK cells, nor was it able to affect the number of IL- 2- induced LAK cells and to alter the lytic activity of LAK cells against tumor cells in effector phase. However, when IL- 6 was used in combination with IL- 2 during the induction phase, the resulting LAK cells displayed considerably greater lytic, activity than that with IL-2 alone (P<0.01), and this effect was IL-6 dose-dependent. The possible machanism of the synergistic effect of IL-2 and IL-6 in LAK cell induction from human fetal spleen is discussed.
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Lu, L., Cui, Z., Zhang, L. et al. Experimental study on interleukin 6 activity against tumor; Regulation of interleukin-2 induced lak cell activity. Chin J Cancer Res 5, 263–267 (1993). https://doi.org/10.1007/BF03023757
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DOI: https://doi.org/10.1007/BF03023757