Is propofol neurotoxic to the developing brain?

Le propofol estil neurotoxique pour le cerveau en développement ?

References

  1. 1

    U.S. Food and Drug Administration. Center for drug evaluation and research. Pediatric Exclusivity Labeling Changes as of July 14, 2006. Available from URL; http://www.fda.gov/cder/pediatric/labelchange.htm.

  2. 2

    Parke TJ, Steven JE, Rice AS, et al. Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports. BMJ 1992; 305:613–66.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  3. 3

    Withington D, Decell MK, Al Ayed T. A case of propofol toxicity: further evidence for a causal mechanism. Pediatr Anesth 2004; 14:505–88.

    Article  Google Scholar 

  4. 4

    Kang TM. Propofol infusion syndrome in critically ill patients. Ann Pharmacother 2002; 36:1453–6.

    Article  PubMed  Google Scholar 

  5. 5

    Reynolds JE. Martindale’s The Extra Pharmacopoeia, 29th ed. London: The Pharmaceutical Press; 1989:949–72..

    Google Scholar 

  6. 6

    Saravanakumar K, Venkatesh P, Bromley P. Delayed onset refractory dystonic movements following propofol anesthesia. Pediatr Anesth 2005; 15:597–6011.

    CAS  Article  Google Scholar 

  7. 7

    Al-Jahdari WS, Saito S, Nakano T, Goto F. Propofol induces growth cone collapse and neurite retractions in chick explant culture. Can J Anesth 2006; 53:1078–855.

    Article  PubMed  Google Scholar 

  8. 8

    Kandel ER, Schwartz JH, Jessell TM. Principles of Neural Science, 4th ed. New York: McGraw-Hill; 2000: 1070–4.

    Google Scholar 

  9. 9

    Jauniaux E, Gulbis B, Shannon C, Maes V, Bromley L, Rodeck C. Placental propofol transfer and fetal sedation during maternal general anaesthesia in early pregnancy. Lancet 1998; 352: 290–1.

    CAS  Article  PubMed  Google Scholar 

  10. 10

    Gin T, Gregory MA, Chan K, Oh TE. Maternal and fetal levels of propofol at caesarean section. Anaesth Intensive Care 1990; 18:180–4..

    CAS  PubMed  Google Scholar 

  11. 11

    Peeters MY, Prins SA, Knibbe CA, et al. Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery. Anesthesiology 2006; 104: 466–74.

    CAS  Article  PubMed  Google Scholar 

  12. 12

    Raoof AA, van Obbergh LJ, Verbeeck RK. Propofol pharmacokinetics in children with biliary atresia. Br J Anaesth 1995; 74:46–9..

    CAS  Article  PubMed  Google Scholar 

  13. 13

    Knibbe CA, Melenhorst-de Jong G, Mestrom M, et al. Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery. Br J Clin Pharmacol 2002; 54:415–222.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  14. 14

    Murat I, Billard V, Vernois J, et al. Pharmacokinetics of propofol after a single dose in children aged 1-3 years with minor burns. Comparison of three data analysis approaches. Anesthesiology 1996; 84:526–322.

    CAS  Article  PubMed  Google Scholar 

  15. 15

    Health Canada. Therapeutic product directorate. Important safety concerns re use of propofol for sedation in pediatric patients. Health Products and Food Branch. Notice to Hospitals. May 1, 2001. Available from URL; http://www.hs-sc.gc.ca/dhp-mps/medeff/advisories-avis/prof/2001/index_ehtm.

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Hossam El Beheiry or Brian Kavanagh.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Beheiry, H.E., Kavanagh, B. Is propofol neurotoxic to the developing brain?. Can J Anesth 53, 1069 (2006). https://doi.org/10.1007/BF03022872

Download citation