Summary and Conclusions
The circulatory response in the supine position and in the 60° head-up tilt was compared in eight healthy male subjects with a therapeutic dose of f trimethobenzamide, trimeprazine, diphenhydramine; dimenhydrinate, cyclizine, methaminodiazepoxide, and haloperidol. None of these drugs caused a significant alteration in the pulse rate or blood pressure, even in the head-up tilt position. Aside from drowsiness, none of the drugs except Haloperidol caused undesirable side-effects.
Résumé
Nous avons comparé chez huit sujets mâles en teanté, la réponse circulatoire à une élévation de la tête de 60°, après une dose thérapeutique de triméthobenzamide, de triméprazine, de diphenhydramide, de cyclizine, de méthaminodiazepoxide et de halopéridol. Aucun de ces médicaments n’a causé de changement important de la vitesse du pouls ou de la tension artérielle. Si ľon excepte les étourdissements, aucun de ces médicaments, à part ľhalopéridol, n’a causé ďeffets secondaires indésirables.
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References
Dobkin, A. B., Keil, A. M., &Wong, G. Circulatory Response to Tilt with Phenothiazines. Anaesthesia16: 160 (April, 1961).
Dobkin, A. B., &Criswick, V. G. Circulatory Response to Tilt with Narcotic Analgesics in Normal Healthy Male Subjects. Anesthesiology22: 398 (May, 1961).
Dobkin, A. B., &Criswick, V. G. The Antisialogogue Effect of Trimethobenzamide HC1 (Tigan®), Trimeprazine Tartrate (Panectyl®), Diphenhydramine HCL (Benadryl®), Dimenhydrinate (Gravol®, Dramamine®) and Cyclizine Lactate (Marzine®, Marezine®). Canad. Anaesth. Soc. J.8:, 154 (March, 1961).
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From the Department of Anaesthesia, University of Saskatchewan College of Medicine and University Hospital, Saskatoon, Sask.
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Dobkin, A.B., Criswick, V.G. Circulatory response to tilt with some anti-emetic and sedative drugs. Can. Anaes. Soc. J. 8, 387–393 (1961). https://doi.org/10.1007/BF03021357
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DOI: https://doi.org/10.1007/BF03021357