Étude de la cohorte nord-finlandaise de 1966: facteurs prédictifs et conséquences de la schizophrénie

Predictors and consequences of schizophrenia in the Northern Finland 1966 birth cohort

Résumé

Des anomalies de la cognition, de la motricité fine, des émotions et du comportement sont fréquentes chez les enfants apparemment sains, qui plus tard développeront une schizophrénie. Ces éléments suggèrent que certains facteurs favorisants sétablissent bien avant que le diagnostic de psychose ne soit fait. Nous avons tenté de recenser les facteurs contribuant au développement des schizophrénies. Nous nous sommes polarisés sur les facteurs génétiques, les complications de la grossesse et de l’accouchement, le développement précoce, les performances scolaires ainsi que sur les retentissement physique et social. Ce travail est basés sur une revue des travaux scientifiques, des articles publiées et des recherches en cours concernant la cohorte nord-finlandaise de 1966.

Abstract

Subtle motor, emotional, cognitive and behavioural abnormalities are often present in apparently healthy children and adolescents who later develop schizophrenia. This suggests that some aspects of causation are established long before psychosis becomes manifest. We aim to assess the factors contributing to the development of schizophrenia focusing mainly on genetic factors, pregnancy and delivery complications, early development and scholastic performance, as well as later educational, social and health consequences. This is done by reviewing the Northern Finland 1966 Birth Cohort, its scientific activities, publications and work in progress.

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Correspondence to Matti Isohanni.

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Traduction de l’anglais: Caroline Demily (Rouen)

Ce travail a été rendu possible grâce aux subventions de la Finnish Academy, de la Sigrid Juselius Foundation et de la Theodore & Vada Stanley Foundation.

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Isohanni, M., Croudace, T., Isohanni, I. et al. Étude de la cohorte nord-finlandaise de 1966: facteurs prédictifs et conséquences de la schizophrénie. Psychiatr Sci Hum Neurosci 3, S8 (2005). https://doi.org/10.1007/BF03020590

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Mots-Clés

  • Schizophrénie
  • Développement
  • Grossesse
  • Facteurs prémorbides
  • Modèles prédictifs

Keywords

  • Schizophrenia
  • Development
  • Pregnancy
  • Premorbid features
  • Predictive models