Abstract
The time to loss of the adductor pollicis muscle response to ulnar nerve stimulation at 1 Hz (twitch) after succinylcholine, 1.5 mg·kg-1 intravenously (IV), or vecuronium, 0.1 mg·kg-1 (IV), administration was assessed visually in 134 children, age 2-13 yr, during clinically determined, deep halothane, enflurane and isoflurane anaesthesia. The overall time to twitch ablation and duration of succinylcholine’s action is in agreement with published times obtained under controlled experimental conditions; the onset time following vecuronium is comparable to those observed during a simitar anaesthetic background measured under controlled experimental conditions. Twitch ablation after succinylcholine was achieved in half the time needed following vecuronium regardless of anaesthetic agent. Succinylcholine’s and vecuronium’s onset time as well as succinylcholine’s duration is adequately assessed by the outlined, simple clinical means. The choice of inhalation agent does not affect the time to visible twitch ablation in a clinically relevant manner; nor does it make an appreciable difference, in clinical terms, in succinylcholine’s duration of action.
Résumé
Le temps de perte de la réponse du muscle adducteur du pouce suite à une stimulation du nerf cubital à 1 Hz (twitch) après 1.5 mg·kg-1 (IV) de succinylcholine, ou 0.1 mg·kg-1 intraveineux de vécuronium a été évalué visuellement chez 134 enfants âgés de 2 à 13 ans durant une anesthésie profonde à ľhalothane, enflurane et isoflurane. Le temps de perte de la réponse musculaire et la durée de ľaction de la succinylcholine sont en accord avec les temps déjà publiés lors des conditions expérimentales contrôlées; le début ďaction après vécuronium est comparable à celui observé dans les conditions expérimentales contrôlées. La perte de la réponse musculaire après succinylcholine a été acquise deux fois plus rapidement qu’avec le vécuronium indépendamment de ľagent anesthésique utilisé. Le début ďaction de la succinylcholine et du vécuronium ainsi que la durée ďaction de la succinylcholine peuvent être adéquatement évalués cliniquement. Le choix de ľagent anesthésique ďinhalation n’affecte pas le temps de la perte de la contraction musculaire ďune façon cliniquement significative et ne présente aucune différence cliniquement appréciable dans la durée ďaction de la succinylcholine.
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Reynolds, P.I., Fang, W.B. & VanDerSpek, A.F.L. The onset of ablation of the evoked adductor pollicis muscle twitch in children: a clinical perspective. Can J Anaesth 35, 576–580 (1988). https://doi.org/10.1007/BF03020343
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DOI: https://doi.org/10.1007/BF03020343