Abstract
We compared two narcotic/N2O anaesthetic techniques and an inhalational anaesthesia/N2O technique for outpatient surgery in 59 women undergoing short gynaecological procedures. All patients received droperidol 0.625 mg IV, thiopentone and 70 per cent N2O in O2 plus either alfentanil (15 µg · kg-1 ), fentanyl (1.5 µg · kg-1) or enflurane. The narcotics were given in a double-blind fashion and all anaesthetic techniques were assigned randomly. Cardiorespiratory parameters remained stable in all groups, with few clinically important changes occurring. Recovery was significantly faster in the group receiving alfentanil, with the time to respond to verbal commands and the time to establish alertness significantly faster than with either fentanyl or enflurane. All techniques provided satisfactory anaesthesia; however, the patients receiving alfentanil had significantly more adverse events than those receiving fentanyl.
Résumé
On a comparé deux techniques anesthésiques utilisant des narcotiques avec protoxyde ďazote et une technique utilisant de ľenflurane protoxyde ďazote chez 59 patientes externes devant subir des procédures gynécologiques de courte durée. Toutes les patientes ont reçu du dropéridol 0.625 mg IV, du thiopentone et 70 pour cent de protoxyde ďazote dans ľoxygène et soit de ľalfentanil (15 µg·kg-1), du fentanyl (1.5 mg·kg-1) ou de ľenflurane. Les narcotiques ont été donnés à double insu et les techniques anesthésiques ďinhalation furent randomisées. Les paramètres cardiorespiratoires sont demeurés stables chez toutes les patientes dans les trois groupes et peu de changements cliniquement importants sont survenus. La récupération était significativement plus rapide chez le groupe ayant reçu de ľalfentanil avec un temps de réponse à la commande verbale significativement plus court que celui du fentanil ou de ľenflurane. Toutes les techniques ont fourni une anesthésie satisfaisante. Cependant le groupe ayant reçu de ľalfentanil avait significativement plus Ďeffets secondaires que celui ayant reçu de fentanyl.
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References
Fatton CM, Moon MR, Dannemiller FJ. The prophylactic antiemetic effect of droperidol. Anesth Analg 1974; 53: 361–4.
Iwamoto K, Schwartz H. Antiemetic effect of droperidol after ophthalmic surgery. Arch Ophthalmol 1978; 96: 1378–9.
Rita L, Goodarzi M, Seleny F. Effect of low-dose droperidol on postoperative vomiting in children. Can Anaesth Soc J 1981; 28: 259–62.
Ryan T. Significant tests for multiple comparisons of proportions, variances and other statistics. Psychol Bull 1960; 57: 318–28.
Kay B, Venkataraman P. Recovery after fentanyl and alfentanil in anaesthesia for minor surgery. Br J Anaesth 1983; 55: 169S.
Patrick M, Eagar B, Toft DF, Sebel PS. Alfentanil supplemented anaesthesia for short procedures: a doubleblind comparison with fentanyl. Anaesthesiology 1983; 59: A346.
Sinclair ME, Cooper GM, Alfentanil and recovery. Anaesthesia 1983; 38: 435–7.
Patrick M, Eagar BM, Toft DF, Sebel PS. Alfentanil-supplemented anaesthesia for short procedures. Br J Anaesth 1984; 56: 861–5.
Bidabe AM, Floras P, Gin AM, Dartiques F, Sabathie M, Caille M. Alfentanil as a supplement to neuroradioanaesthesia. Comparison with Fentanyl. J Neuroradiology 1985; 12: 191–9.
Antonios WRA, Inglis MD, Lees NW. Alfentanil in minor gynaecological surgery: use with etomidate and a comparison with halothane. Anaesthesia 1984; 39; 812–5.
Coe V, Shafer A, White PF. Techniques for administering alfentanil during outpatient anaesthesia — a comparison with fentanyl. Anaesthesiology 1983; 59: A347.
Rein J. Alfentanil in anaesthesia and analgesia. Drug Intelligence and Clinical Pharmacology 1986; 20: 335–41.
Kay B, Cohen AT, Shaw F, Healy TEJ. Anaesthesia for laparoscopy: alfentanil and fentanyl compared. Annals of the Royal College of Surgeons of England 1983; 65: 316–7.
van Leeuwen L, Deen L. Alfentanil, a new, potent and very short-acting morphinomimetic for minor operative procedures. Anaesthetist 1981; 30: 115–7.
Kay B, Stephenson DK. Alfentanyl (R39209): initial clinical experience with a new narcotic analgesic. Anaesthesia 1980; 35: 1197–1201.
Bovili JG, Sebel PS, Blackburn CL, Heykants J. The pharmacokinetics of alfentanil (R39209): a new opioid analgesic. Anaesthesiology 1982; 57: 439–43.
Palazzo MGA, Taylor S, Strunin L. Clinical experience with alfentanil for the induction of anaesthesia; a comparison with thiopentone. Can Anaesth Soc J 1984; 31: 517–22.
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Haley, S., Edelist, G. & Urbach, G. Comparison of alfentanil, fentanyl and enflurane as supplements to general anaesthesia for outpatient gynaecologic surgery. Can J Anaesth 35, 570–575 (1988). https://doi.org/10.1007/BF03020342
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DOI: https://doi.org/10.1007/BF03020342