Abstract
Streptomycin causes toxicity due to direct action on the organs in labyrinth. The bioavailability of drug is dependent on its dosage, absorption, metabolism and excretion. Individual variables like age, sex, nutrition, haemoglobin levels. renal functions do not appear to lead to predispose the ototoxicity. The drug dosage and combinations of other drugs were considered in studying the ototoxicity. It is observed that serum levels of more than 2.5 microgram per milliliters predispose dispose to ototoxicity. So also the subjects having higher than 2.5 mgms/ml in serum at the 24th hour following single injection of drug are more vulnerable, (P<0.05) on the otherhand initial higher level at the end of 1st hour (mean 54.75 ugm/ml) do not have positive relationship with toxicity (P<0.05). Furthermore streptomycin appears to be more damaging to static than dynamic part of labyrinth and the later is more vulnerable than cochlear.
Similar content being viewed by others
References
Berg (1951) : Toxic effect of streptomycin on vestibular and cochlear afferents, an experimental study in casts,Acta Suppl. 97.
Bignell, J. R., and Thomas, J. A. B. (1951): Effect of streptomycin on vestibular function,British Medical Journal,1 : 554.
Bosher (1976) : S. K. Scientific Foundation of Otolaryngology Ed. Hinchliffe, R. and HarrisonD.F. M. London, Heinemann Page 292.
Cruickshank, R. (1975) in Medical Microbiology London, Edinburgh,Churchill Livingston 12th Ed. Vol. II.
Farrington, R. F., Hull Smith, H., Bunn, P. A. and Mc Dermott, W. Streptomycin toxicity,Journal American Medical Association,134 : 679.
Leggat and Girifford (1952) Uncommon neurotoxic Symptom associated with Dihydrostreptomycin therapy,British Medical Journal 1: 1008.
Mishra, S. C. & Bera, S. P. (1981) Neurootological profile of streptomycin ototoxicity, Indian Journal ofOtolaryngology 33:1.
Tumarkin (1951) in Scientific Foundation in Otolaryngology, Ed. Hinchcliffe R. and Harrison,London, Hencmann, 1976.
Yassin, A and Taha, M, (1965) Hearing disorders in Secondary Anaemia,Journal of Larynglogy and Otology,79: 917.
Author information
Authors and Affiliations
Additional information
An erratum to this article is available at http://dx.doi.org/10.1007/BF02995370.
Rights and permissions
About this article
Cite this article
Bhateja, D.K., Mishra, S.C., Nath, J. et al. Aetiopathology of the streptomycin ototoxicity. Indian J Otolaryngol 38, 69–71 (1986). https://doi.org/10.1007/BF03020144
Issue Date:
DOI: https://doi.org/10.1007/BF03020144