Abstract
Muscle rigidity, a persistent physiological characteristic of the nervous Pointer dog, is not only attenuated by the major neuroleptic drugs, haloperidol and pimozide but also by naloxone. In addition, naloxone administration results in a modest but significant increase in heart rate of these subjects. The data obtained in this study add support for the concept that an abnormality in central nervous system dopaminergic function is involved in the genesis of abnormal behavior of this animal model.
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Supported in part by the Veterans Administration and in part by a Graduate Student Institutional Research Grant awarded to Dr. Shideler by the University of Arkansas for Medical Sciences.
The authors appreciate the valuable technical assistance of Letha Couch, T. C. Moody and Martha Marrow.
The naloxone use is this study was generously supplied by Endo Laboratories, Garden City, N.Y., and the haloperidol and pimozide were generously supplied by McNeil Laboratories, Fort Washington, Pa.
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Shideler, C.E., DeLuca, D.C., Newton, J.E.O. et al. Effects of naloxone and neuroleptic drugs on muscle rigidity and heart rate of the nervous Pointer dog. Pav. J. Biol. Sci. 18, 211–215 (1983). https://doi.org/10.1007/BF03019354
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DOI: https://doi.org/10.1007/BF03019354