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The precipitate formed by thiopentone and vecuronium

Canadian Journal of Anaesthesia volume 43, pages 511–513 (1996)Cite this article

Abstract

Purpose

To determine the composition and solubility of the precipitate formed by thiopentone and vecuronium in vitro.

Methods

The precipitate formed by mixing thiopentone 2.5% and vecuronium 0.1% at room temperature was analyzed by ultraviolet spectrophotometry and high performance liquid chromatography (HPLC). The solubility of the precipitate in human plasma was measured by HPLC.

Results

The UV absorption spectrum of the precipitate, resembled that of thiopentone. HPLC analysis produced a single peak with the same retention time as thiopentone (4.6 min). In human plasma the solubility of the precipitate was not different from that of thiopentone acid. The solubility of thiopentone was greater than that of the precipitate.

Conclusion

The precipitate formed by thiopentone and vecuronium in vitro consisted of thiopentone acid, which was insoluble in human plasma.

Résumé

Objectif

Determiner la composition et la solubilité du précipité formé par le thiopentone et le vécuronium in vitro.

Méthodes

La précipité formé par le mélange de thiopentone 2,5% et de vécuronium 0,1% à la température de la pièce a été analysé par spectrométrie aux rayons ultraviolets et par chromatographie en phase liquide à haute performance (CPLH). Chez l’humain, la solubilité du précipité a été mesuré par CPHL.

Résultats

L’absorption du spectre ultraviolet du précipité était identique à celle du thiopentone. L’analyse par CPLH produit un seul pic avec le même temps de rétention que le thiopentone (4,6 min). Dans le plasma humain, la solubilité du précipité de différait pas de celle de l’acide de thiopentone. La solubilité du thiopentone était plus grande que celle du précipité.

Conclusion

La précipité formé par le thiopentone et le vécuronium in vitro consistait en acide de thiopentone lequel est insoluble dans le plasma.

References

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  2. Blackman GL, Jordan GJ, Paull JD. Analysis of thiopentone in human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl 1978; 145: 492–5.

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  3. Wade A. Halothane and general anaesthetics.In: Wade A (Ed.). The Extra Pharmacopoeia, 27th ed. London: The Pharmaceutical Press, 1977: 710–3.

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Author information

Affiliations

  1. Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920, Kanazawa, Japan

    Takumi Taniguchi, Ken Yamamoto & Tsutomu Kobayashi

Authors
  1. Takumi Taniguchi
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  2. Ken Yamamoto
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  3. Tsutomu Kobayashi
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Taniguchi, T., Yamamoto, K. & Kobayashi, T. The precipitate formed by thiopentone and vecuronium. Can J Anesth 43, 511–513 (1996). https://doi.org/10.1007/BF03018114

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  • DOI: https://doi.org/10.1007/BF03018114

Key words

  • anaesthetics, intravenous: thiopentone
  • neuromuscular relaxants: vecuronium
  • drug interactions: thiopenlone, vecuronium