Summary
Two hundred patients were given Chlorpromazine and Demerol intramuscularly during labour. Hypnosis and analgesia were found to be unpredictable. No appreciable alterations were noted m patient’s pulse, blood pressure, or foetal heart rate in the normo-tensive patients. The amount of opiates during labour and of anaesthesia during delivery was lessened. Nausea and vomiting were practically absent, and no ill effects on the babies were noted.
Promethazme was given in the same way to 300 patients in labour. A satisfactory sedative dose was reasonably predictable. Hypnosis and analgesia from Demerol were appreciably potentiated by the drug. The labour rooms were noticeably quieter and the patients less concerned about their labour. As with Chlorpromazine, anaesthesia for delivery was decreased and the incidence of nausea and vomiting became remarkably low. The drug appeared to have no depressing or other undesired effect on the baby. It was our impression that Promethazme and Demerol given during labour offer the mother more effective sedation and her baby less harm, than any combination of drugs with which we are acquamted.
Résumé
Deux cents patients reçurent durant leur travail, du Chlorpromazine et du Démérol en mtra-musculaire. Il lut possible de prévoir l’hypnose et 1’analgésie. Chez celles à tension arténelle normale on ne nota pas de changement appréciable du pouls et de la tension de même que des pulsations cardiaques foetales.
On a pu restremdre l’emploie des opiacés au cours du travail et de l’anesthésie au moment de la délivrance Il n’y eut pratiquement pas de nausées et vomissements et aucun effet nocif put être noté chez les nouveaux-nés. Dans les mêmes circonstances, chez trois cents patients en travail, on donna du Promethazine.
It fut possible de prédire de façon raisonable une dose sédative satisfaisante. Les effets hypnotiques et analgésiques du Démérol furent augmentés de façon appréciable. Les salles d’accouchement devinrent plus tranquilles et les patients moins effrayées du travail. Comme avec le Chlorpromazine, l’anesthésie pour la déhvrance put être réduite et l’incidence des nausées et vomissements devint très basse
Le médicament ne semble pas avoir d’effets depresses ou indésirés sur le bébé. L’impression des auteurs fut que le Promethazine et le Démérol donnés durant le travail offrent a la mère une sédation plus eflective et à son bébé, moms de danger que n’importe laquelle combmaison de medicaments que nous connaissons.
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Carroll, J.J., Hudson, P.W. Chlorpromazine and promethazine in obstetrics. Canad. Anaesth. Soc. J. 2, 340–346 (1955). https://doi.org/10.1007/BF03015876
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DOI: https://doi.org/10.1007/BF03015876