Abstract
Midazolam is a water soluble benzodiazepine of interest to the anaesthetist for use as a premedicant and for induction of anaesthesia. The effects of midazolam were observed on the resting tension of directly stimulated muscle biopsied from control and malignant hyperthermia (MH) susceptible patients. In addition, interactions between midazolam and the two most commonly used MH diagnostic agents (halothane and caffeine) were examined. Midazolam, at maximum therapeutic concentrations (ca. 0.5 ng·ml-1), had no detectable effects on muscle contraction in preparations from control or MH positive patients. Midazolam did elict a contracture from control and MH positive preparations when used in a concentration range of 160–1280 μg·ml-1. There was no significant difference between control and MH positive patients in minimum concentration of midazolam causing contracture or the strength of contracture at the respective eliciting concentration. There appears to be no interaction between midazolam and either halothane or caffeine on the resting tension of the directly stimulated muscle twitch preparation.
Résumé
Le midazolam est une benzodiazépine hydrosoluble pouvant être utilisable en prémédication ou pour l’induction de l’anesthésie. On a étudié les effets du midazolam sur la tension de repos de fibres musculaires stimulées directement; les biopsies musculaires venaient de patients normaux el d’autres susceptibles à l’hyperthermie maligne. On a aussi étudié les interactions entre le midazolam el les deux agents les plus couramment employés pour le diagnostic de l’HM (halothane et caféine). Le midazolam à des concentrations thérapeutiques maximales (ca. 0.5 μg·ml-1) n’a aucun effet détectable sur la contraction musculaire des préparations normales et susceptibles d l’HM. On a montré une contracture au midazolam chez les deux groupes à des concentrations de 160–1280 μg·ml-1. Il n’y avait pas de différence significative entre les contrôles et les HM dans la concentration minimale de midazolam amenant une contracture ou dans la force de la contracture à la même concentration. Il n’y a pas d’interaction entre le midazolam et l’halothane ou la caféine sur la tension de repos du muscle directement stimulé.
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Supported by a grant from Hoffmann-LaRoche, Inc., Nutley, NJ.
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Fletcher, J.E., Rosenberg, H. & Hilf, M. Effects of midazolam on directly stimulated muscle biopsies from control and malignant hyperthermia positive patients. Can Anaesth Soc J 31, 377–381 (1984). https://doi.org/10.1007/BF03015405
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DOI: https://doi.org/10.1007/BF03015405