Abstract
Our study sought to determine whether premedication with intramuscular midazolam would decrease the time to induction of anaesthesia with intravenous midazolam, and if so whether induction of anaesthesia would be as rapid as with thiopentone or ketamine, intravenously. Eighty-nine patients, ASA physical status I or II, receivedmidazolam0.2 mg · kg-1, thiopentone 3.0 mg · kg-1, or ketamine 2.0 mg · kg-1 intravenously 60–90 min after intramuscular injection of either midazolam 0.07 mg · kg-1 or matching placebo. Time to induction of anaesthesia or the dose required to induce anaesthesia with intravenous midazolam was not decreased by midazolam premedication. Both with or without premedication, midazolam induction time was longer than with thiopentone or ketamine. Midazolam induction was associated with a lower incidence of blood pressure increase than with ketamine induction, and a lower incidence of apnea than that with either thiopentone or ketamine.
Résumé
Notre étude cherche à démontrer si une prémédication avec le midazolam IM diminuera le temps d’induction de l’’Vanesthésie avec le midazolam IV et si cette induction sera aussi rapide qu’avec le thiopental ou la kétamine IV. Quatre-vingt-neuf patients, ASA I ou II, ont reçu midazolam 0.2 mg·kg-1, thiopental 3.0 mg·kg-1 ou kétamine 2.0 mg·kg-1 IV 60’90 minutes apres une injection IM de midazolam 0.07mg·kg-1 ou de placebo. Le temps d’’induction ou la dose requise pour amener l’anesthésie n’ont pas été reduits par laprémédication au midazolam. Avec ou sans prémédication le temps d’induction du midazolam a été plus long que celui du thiopental ou de la ketamine. Le midazolam a été associé à une incidence plus faible d’augmentation de la pression artérielle que la kétamine et à une plus basse incidence d’apnée que le thiopental ou la kétamine.
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Samuelson PN, Reves JG, Kouchoukos NT, Smith LR, Cole KM. Hemodynamic responses to anesthetic induction with midazolam and diazepam in patients with ischemic heart disease. Anesth Analg 1981; 60:802–9.
Reves JG, Samuelson PN, Lewis S. Midazolam maleate induction in patients with ischaemic heart disease: haemodynamic observations. Can Anaesth Soc J 1979; 26:402–7.
Lebowitz PW, Cote ME, Daniels AL, et al. Comparative cardiovascular effects of midazolam and thiopental in healthy patients. Anesth Analg 1982:61:771–5.
Maltby JR, Hamilton RC. Comparison of midazolam and thiopental as induction agents for general anaesthesia (Abstract). Can Anaesth Soc J 1981; 28:500
White PF. Comparative evaluation of intravenous agents for rapid sequence induction—thiopental, ketamine, and midazolam. Anesthesiology 1982; 57:279–84.
Conner JT, Katz RL, Pagano RR, Graham CW. RO-21-3981 for intravenous surgical premedication and induction of anaesthesia. Anesth Analg 1978; 57:1–5.
Fragen RJ, Gahl F, Caldwell N. A water-soluble benzodiazepine, RO-21-3981, for induction of anesthesia. Anesthesiology 1978; 49:41–3.
Reves JG, Vinik R, Hirschfield AM, Holcomb C, Strong S. Midazolam compared with thiopentone as a hypnotic component in balanced anaesthesia: a randomized, double-blind study. Can Anaesth Soc J 1979; 26:42–9.
Finucane BT, Judelman J, Braswell R. Comparison of thiopentone and midazolam for induction of anaesthesia: influence of diazepam premedication. Can Anaesth Soc J 1982; 29:227–30.
Miller R, Eisenkraft JB, Thys DM, Toth C, Bohmer FA, Melmed AP. Comparison of 1M midazolam with hydroxyzine as preanesthetic medications. Anesthesiology Rev 1982; 9:15–9.
Vinik HR, Reves JG, Wright D. Premedication with intramuscular midazolam: a prospective randomized double-blind controlled study. Anesth Analg 1982; 61:933–7.
Gamble JS, Kawar P, Dundee JW, Moore J, Briggs LP. Evaluation of midazolam as an intravenous induction agent. Anaesthesia 1981; 36:868–73.
Fragen RJ, Caldwell NJ. Recovery from midazolam used for short operations (Abstract). Anesthesiology 1980; 53(Suppl):S11.
Miller R, Eisenkraft JB, Jaffe DH, Dimich I, Thys DN, Azer SA. Comparison of midazolam with thiopental for anaesthesia induction. Anesthesiology Rev 1980; 7:21–7.
Schulte-Sasse U, Hess W, Tarnow J. Haemodynamic responses to induction of anaesthesia using midazolam in cardiac surgical patients. Br J Anaesth 1982;54:1053–4.
Alkhudhairi D, Witwam JG, Chakrabarti MK, Askitopoulou H, Grundy EM, Powrie S. Haemo-dynamic effects of midazolam and thiopentone during induction of anaesthesia for coronary artery surgery. Br J Anaesth 1982; 54:831–4.
Jensen S, Hottel S, Olsen AS. Venous complications after IV administration of diazemulus (diazepam) and dorcium (midazolam). Br J Anaesth 1981;53:1083–5.
Vinik R, Reeves JG, Nixon D, Whelchel J, McFarland L. Midazolam induction and emergence in renal failure patients (Abstract). Anesthesiology 1981; 55(Suppl):A262.
Bovill JB, Clarke RSJ, Dundee JS, Pandit SK, Moore J. Clinical studies of induction agents. XXXVIII: effects of premedicants and supplements on ketamine anaesthesia. Br J Anaesth 1971; 43:600–8.
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Supported in part by a grant from Hoffman-LaRoche, Inc., Nutley, New Jersey 07110.
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Artru, A.A., Dhamee, M.S. & Seifen, A.B. Premedication with intramuscular midazolam: Effect on induction time with intravenous midazolam compared to intravenous thiopentone or ketamine. Can Anaesth Soc J 31, 359–363 (1984). https://doi.org/10.1007/BF03015402
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DOI: https://doi.org/10.1007/BF03015402