The effect of hypo-osmolar solutions with hibitane on shed cancer cells in peritoneal cavity of patients with gastric cancer

Abstract

For 100 patients with gastric cancer, intraoperative intraperitoneal perfusion(IOIPP) using double - distilled water (D. D. W) with hibitane 37°C for 5 minutes was performed. The anticancer effects were assessed cytologically in pre - IOIPP and post-IOIPP specimens of the abdominal effusion and/or lavaged peritoneal fluid. The radical gastrectomy was performed in 65 of 93 cases with advanced gastric cancer, shed cancer cells in peritoneal cavity were detected in 16 of 65 cases with pre - IOIPP (24.62%) and in 3 of post - IOIPP cases (4.62%). There was significant difference between the two groups (P<0.01). Shed cancer cells were inactivatedin vivo estimated by the trypan - blue staining technique in 7 cases with radical surgery. But the effect of the IOIPP on shed cancer cells was not significant in cases with peritoneal metastasis. Also there were shed cancer cells in peritoneal cavity of patients with SS cancer histologically before the IOIPP (15.56%) and iatrogenic diffusion of cancer cells during operation (7/24) in thisarticle. The above results indicated that the IOIPP with hypo - osmolar solution containing hibitane, 37°C for 5 mm was indispensable and useful for the killing of peritoneal shed cancer cells in order to prevent postoperative peritoneal recurrence in patients with radical surgery of advanced gastric cancer regardless of conditions of serosal invasion.