Abstract
In this article, the significance of radioimmunoimaging (RII) as a mornitoring means for gastric colorectal and lung cancer patients was reported. By using I - 131 or Tc - 99m labeled C50 (antiCEA) and 3H11 (anti human gastric cancer), 86 positive lesions were identified in 50 cancer patiens. 77 out of the 86 lesions (89.5%) were true positive, 4 false positive by post - surgecal pathology, biopsy or CT scan. The other 5 remained to be unexplained and needed further follow-up.
In our clinical practice, RII with antitumor McAbs suggested its unique value in the management of cancer patients. Totally, 14 occult lesions in 9 cancer patients missed by the other examination were identified by this technique. And owing to the RII findings, all of these patients got proper treatment in time.
Similar content being viewed by others
References
Goldenberg DM, Larson SM. Radioimmunodetection in cancer identification. J Nucl Med 1992; 33:803.
Goldenberg DM, Goldenberg H, Sharkey RM, et al. Clinical studies of cancer radioimmunodetection with carcinoembryonic antigen monoclonal antibody fragments labeled with123I or99mTc. Cancer Res 1990; 50:909.
Patt YZ, Lamki LM, Shanken J, et al. Imaging with indium- 111 - labeled anticarcinoembryonic antigen monoclonal antibody ZCE - 025 of recurrent colorectal or carcinoembryonic antigen - producing cancer in patients with rising serum carcinoembryonic antigen levels and occult metastasis. J Clin Oncol 1990; 8:1246.
Doerr RJ, Hani Abdel Nabi, Merchat B, et al. Indium- 111 ZCE - 025 immunoscintigraphy in occult recurrent colorectal cancer with elevated carcinoembryonic antigen level. Arch Surg 1990; 125:226.
Haseman MK. Radioimmunodetection of occult cancer. Antibody Immunoconj Radiopharm 1992; 5:249.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lin, B., Yang, Z., Zhang, Q. et al. The significance of radioimmunoimaging in the management of cancer patients. Chin J Cancer Res 7, 115–120 (1995). https://doi.org/10.1007/BF03014407
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03014407