Summary
We have studied the effects of Althesin on preganglionic cervical sympathetic nervous activity, arterial pressure, pulse rate and bare-static reflexes in cats. Normal, baroreceptor denervated and decerebrate animals were studied. On the basis of our finding it is concluded that Althesin severely depresses sympathetic nervous activity by action on the vasomotor centre. The depression of arterial pressure however was only moderate due to two compensatory mechanisms: a vagolytic action of Althesin and a peripheral vascular effect believed to be caused by an enhanced action of catecholamines caused by Althesin. Barostatic reflexes were found active under conditions where Althesin did not totally abolish sympathetic tone.
Résumé
Nous avons étudié les effets de l’althesin sur l’activité nerveuse préganglionnaire cervicale sympathique, la pression artérielle, la fréquence cardiaque et les réflexes des barorécepteurs chez le chat. Les études ont été effectuées chez des animaux normaux, décérébrés et dont les barorécepteurs avaient été dénervés. D’après les résultats, nous pouvons conclure que l’althesin déprime de façon importante l’activité nerveuse sympathique par son action sur le centre vaso-moteur. La diminution de la pression artérielle était cependant peu marquée, due à des mécanismes compensateurs: fréquence d’une action vagolytique de l’althesin et d’un effet vasculaire péripérique possiblement dû à l’action amplifiée des catécholamines causée par l’althesin. Les réflexes à partir des barorécepteurs étaient présents dans les conditions où l’althesin n’avait pas aboli complètement le tonus sympathique.
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Supported in part by NIH Grant # HL 15392-03.
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Sapthavichaikul, S., Wisborg, K. & Skovsted, P. The effects of althesin on arterial pressure, pulse rate preganglionic sympathetic activity and barostatic reflexes in cats. Canad. Anaesth. Soc. J. 22, 587–600 (1975). https://doi.org/10.1007/BF03013411
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DOI: https://doi.org/10.1007/BF03013411