Abstract
We studied the circulatory responses to laryngoscopy and tracheal intubation in 37 hypertensive patients who received nicardipine 30 μg · kg−1 iv (Group N, n = 12), diltiazem 0.3 mg · kg−1 (Group D, n = 12) or saline placebo (Group C, n = 13) 60 sec before the initiation of laryngoscopy. Anaesthesia was induced with thiopentone 5 mg · kg−1 iv, and succinylcholine 2 mg · kg−1 iv was used to facilitate tracheal intubation after precurarization with vecuronium 0.02 mg · kg−1 iv. In patients in Group C heart rate (HR) increased from 79 ± 14 (baseline) to 110 ± 12 (P < 0.05) associated with tracheal intubation; mean arterial pressure (MAP) increased from 116 ± 8 to 140 ± 77 (P < 0.05) and rate-pressure product (RPP) increased from 13385 ± 2393 to 21251 ± 3883 (P < 0.05). The changes from baseline values in HR and RPP after tracheal intubation in Group D were less than those in Groups C and N (P < 0.05). The increase in MAP following tracheal intubation in Groups N and D was lower than that in Group C (P < 0.05). We conclude that, compared with nicardipine, administration of diltiazem iv is associated with less circulatory response to tracheal intubation in hypertensive patients.
Résumé
Cette étude vise à déterminer, au moment de la laryngoscopie et de l’intubation trachéale, les réponses circulatoires de 37 patients hypertendus. Ces patients reçoivent de la nicardipine 30 μg · kg−1 (groupe N, n = 12), du diltiazem 0,3 mg · kg−1 (groupe D, n = 12) ou un placebo (groupe C, n = 13) 60 sec avant la laryngoscopie. L’anesthésie est induite avec du thiopentone 5 mg · kg−1 iv et la succinylcholine 2 mg · kg−1 iv est administrée pour faciliter l’intubation après précurarisation au vécuronium 0,02 mg · kg−1. Chez les patients du groupe C, la fréquence cardiaque (Fc) augmente de 79 ± 14 à 110 ± 12 (P < 0,05) au moment de l’intubation, la pression artérielle moyenne (PAM) augmente de 116 ± 8 à 140 ± 77 (P< 0,05) et le produit fréquence/pression (PFP) augmente de 13385 ± 2393 à 21251 ± 3883 (P < 0,05). Les changements de la Fc et du PFP depuis la valeur initiale après l’intubation endotrachéale étaient moindres que dans les groupes C et N (P < 0,05). L’augmentation de la PAM dans les groupes N et D était inférieure à celle du groupe C (P< 0,05). Les auteurs concluent que comparativement à la nicardipine, le diltiazem est associé chez les hypertendus à moins de répercussions circulatoires á l’intubation de la trachée.
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This article has been retracted due to two reasons: Many variables reported in the studies are exceedingly unlikely. The author’s institution is not able to attest the integrity of the study and/or the data conducted under its auspices.
An erratum to this article can be found online at http://dx.doi.org/10.1007/s12630-012-9836-z.
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Fujii, Y., Tanaka, H., Saitoh, Y. et al. RETRACTED ARTICLE: Effects of calcium channel blockers on circulatory response to tracheal intubation in hypertensive patients: nicardipine versus diltiazem. Can J Anaesth 42, 785–788 (1995). https://doi.org/10.1007/BF03011177
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DOI: https://doi.org/10.1007/BF03011177