Abstract
Forty patients without eye disease, undergoing elective nonophthalmic surgery, were studied to evaluate the efficacy of sublingual nifedipine in attenuating the intraocular pressure response to succinylcholine administration, laryngoscopy and intubation. The patients were randomly given either nifedipine 10 mg or placebo sublingually 20 minutes before induction of anaesthesia. Intraocular pressure (IOP) and systolic blood pressure (SBP) were recorded before and after induction of anaesthesia. The IOP response to succinylcholine administration, laryngoscopy and intubation was significantly less in patients receiving nifedipine (P > 0.01). The mean maximum rise in IOP above basal level at one minute postintubation was 7.82 mmHg in the control group compared with 0.15 mmHg in the nifedipine pretreated group. These results suggest that sublingual nifedipine is effective in attenuating the IOP response after succinylcholine administration, laryngoscopy and intubation.
Résumé
Nous avons évalué le role de la nifédipine sub-linguale dans la prevention de l’augmentation de la pression intra-oculaire suivant l’injection de succinylcholine et l’intubation chez 40 patients aux yeux normaux. Le hasard déterminait s’ils allaient recevoir 10 mg de nifédipine ou un placebo 20 minutes avant l’induction de leur anesthésie pour chirurgie non-ophtalmique. Nous mesurions les pressions intra-oculaire (PIO) et artirielle systolique (PAS) avant et apres cette induction. L’augmentation maximale moyenne de la PIO une minute après l’intubation a ete de 7.82 mmHg dans le groupe placebo et de 0.15 mmHg dans le groupe nifédipine (P < 0.01). Donc, la nifédipine sublinguale semble capable de limiter l’augmentation de la PIO suivant la séquence succinylcholine-laryngoscopie-intubation trachéale.
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Indu, B., Batra, Y.K., Puri, G.D. et al. Nifedipine attenuates the intraocular pressure response to intubation following succinylcholine. Can J Anaesth 36, 269–272 (1989). https://doi.org/10.1007/BF03010763
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DOI: https://doi.org/10.1007/BF03010763