Abstract
To test the possibility that individuals with and without plasma cholinesterase C5 isozyme have differences in neuromuscular sensitivity to succinylcholine chloride, we examined the effects of succinylcholine in these two groups of patients. Sera from 491 adult patients were examined for presence of the plasma cholinesterase C5 isozyme by use of electrophoresis with polyacrylamide; 24 were positive for the C5 isozyme. Plasma cholinesterase activity and duration of action of succinylcholine were measured in 12 C5 positive patients and 18 C5 negative patients, all of whom had the normal cholinesterase genotype. C5 positive patients had 30.1 per cent higher mean plasma cholinesterase activity than C5 negative patients. The duration of neuromuscular blockade, measured by the first twitch height evoked by train-of-four stimulation, was significantly shorter in C5 positive patients than C5 negative patients. The C5 positive individuals had shorter duration of action of succinylcholine than C5 negative individuals.
Résumé
Afin de vérifier la possibilité que les individus avec ou sans plasma choUnesterase C5 isoenzyme présentent des différences de sensibilité à la succinylcholine, on a examiné les effets de succinylcholine chez ces deux groupes de patients. Les sérums de 491 patients adultes ont été examinés pour la présence de plasma cholinesterase C5 isoenzyme par electrophorese avec le polyacrylamide; 24 etaient positifs pour le C5 isoenzyme. L’activité du plasma choUnesterase et la durée d’action de la succinylcholine ont été mesurée chez 12 patients ayant un C5 positif et 18 patients ayant un C5 négatif tous ayant un génotype normal de choUnesterase. Les patients avec C5 positif ont présenté une activité moyenne de la plasma choUnesterase 30.1 pour cent superieur à celles qui ont présenté un C5 négatif. La durée du bloc neuromusculaire mesurée par la hauteur du premier twitch évoqué par une stimulation d’une ondée de quatre était significativement plus courte chez les patients ayant un C5 positif que ceux qui ont un C5 négatif. Les individus ayant un C5 positif ont présenté une duree d’action de la succinylcholine plus courte que ceux qui ont un C5 négatif.
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Sugimori, T. Shortened action of succinylcholine in individuals with cholinesterase C5 isozyme. Can Anaesth Soc J 33, 321–327 (1986). https://doi.org/10.1007/BF03010744
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DOI: https://doi.org/10.1007/BF03010744