Summary
The effect of intramuscular histidine on gastric secretion was studied in dogs with accessory stomachs and in gastrostomized preparations. In vitro experiments were performed to determine the action of this amino acid on intestinal tone and motility.
Histidine did not decrease the volume or acidity of gastric secretory response to either food or histamine stimulation. In two of three pouch dogs and in one of two gastrostomized dogs there occurred a prolonged and increased secretory response coincident with histidine administration. In organ baths, histidine in physiological concentrations had no effect on the tone or motility of segments of small intestine. The data presented in the above experiments offer no support for the therapeutic claims made for histidine in the treatment of peptic ulcer in man.
Similar content being viewed by others
References
Barry, H. C. and Florey, H. W.: Histidine treatment of peptic ulcer.Lancet, 2:728–734, 1936.
Fauley, G. B. and Ivy, A. C.: Fundusectomy prevents post-operative jejunal ulcer.Proc. Soc. Exper. Biol, and Med., 34:152–154, 1936.
Flood, C. A. and Mullins, C. R.: Experimental peptic ulcer: the effect of surgical duodenal drainage upon dogs, and the value of histidine in preventing ulcers.Amer. Jour. Digest. Dis. and Nutrit., 3:249–255, 1936.
Flood, C. A. and Mullins, C. R.: Treatment of peptic ulcer by means of injection.Amer. Jour. Digest. Dis. and Nutrit., 3:303–305, 1936.
Gardiner, R. H.: Histidine in the treatment of gastric and duodenal ulcer.Lancet, 1:1352–1353, 1936.
Goodman, L., Oilman, A. and Bearg, P.: A simple catheter device for the care of gastric pouch animals.Jour. Lab. and Clin. Med., 22:209–211, 1936.
Hirschfelder, A. D. and Cantwell, W.: Effects of some amino acids upon excised segments of intestine.Jour. Pharm. and Exper. Therap., 11:178, 1918 (Proc).
Ivy, A. C. and Javois, J.: Contributions to the physiology of gastric secretion. V. The stimulation of gastric secretion by amino acids.Amer. Jour. Physiol., 71:591–603, 1925.
Martin, Kirby A.: Histidine hydrochloride versus diet and alkalis in the treatment of peptic ulcer. The immediate and late effects in forty-one cases.Jour. Amer. Med. Assoc, 106:1468–1473, 1936.
Morton, C. B.: III. Healing of experimental peptic ulcer after gastro-enterostomy.Ann. Surg., 85:229–238, 1927.
Sandweiss, D. J., Saltzstein, H. C. and Glazer, W. S.: The value of histidine in prevention of experimental ulcer in dogs.Amer. Jour. Digest. Dis. and Nutrit., 4:20–23, 1937.
Sandweiss, D. J.: The treatment of gastroduodenal ulcer with histidine monohydrochloride (Larostidin).J. A. M. A., 106:1452–1459, 1936.
Sandweiss, D. J.: Comparative results with dietetic, parenteral and surgical treatment in peptic ulcer.J. A. M. A., 108:700–707, 1937.
Stalker, L. K., Bollman, J. L. and Mann, F. C.: Prophylactic treatment of peptic ulcers produced by cinchophen.Amer. Jour. Digest. Dis. and Nutrit., 3:822–827, 1937.
Volini, I. F. and McLaughlin, R. F.: The histidine monohydrochloride therapy of gastroduodenal ulcer. A preliminary report.Med. Rec, 141:364–366, 1935.
Volini, I. F. and McLaughlin, R. F.: The histidine monohydrochloride therapy of gastroduodenal ulcer.Illinois Med. Jour., 69:39–45, 1936.
Weiss, A. G., Aron, E. and Holtzmann, P.: Influence des injections ďacides aminés (tryptophane, histidine, lysine) sur la cicatrisation de plaies artificicielles de la muqueuse gastrique.Compt. rend. Soc. de biol, 113:1067–1069, 1933.
Weiss, A. G. and Aron, E.: Rôle des acides aminés dans ľevolution de ľulcère expérimental: influence de ľhistidine.Presse med., 41:1880–1883, 1933.
Weiss, A. G. and Aron, E.: Orientation nouvelle du problème de ľulcère expérimental: Le rôle de certains acides aminés dans la pathogénie de ľulcère et dans sa thérapeutique.Bull, et mém. Soc. nat. de chir., 59:898–901, 1933.
Windwer, C. and Matzner, M. J.: Histidine in experimental gastric ulcer.Amer. Jour. Digest. Dis. and Nutrit., 3:547–549, 1936.
Additional information
From the department of pharmacology and toxicology, yale university school of medicine.
Rights and permissions
About this article
Cite this article
Louis, S., Goodman, M.D., Philip, A. et al. The action of histidine on the gastro-lntestinal tract. American Journal of Digestive Diseases 5, 117–121 (1938). https://doi.org/10.1007/BF03010609
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03010609