Abstract
This work was presented in part at the 1987 Canadian Anaesthetists’ Society Annual Meeting in Calgary, Alberta.
To determine the onset and recovery times and haemodynamic effects of intubating doses of atracurium (0.4 mg-kg-1), dtubocurarine (0.8 mg-kg-1), pancuronium (0.12 mg-kg-1), and vecuronium (0.07 mg-kg-1), sixty-seven children aged one to eight years were studied under halothane and nitrous oxide anaesthesia. The time to maximum twitch depression and the time to recovery to TIITc 25 per cent were recorded with an integrated evoked EMC recorder. The heart rate and systolic blood pressure were recorded for five minutes after drug administration and prior to intubation. There was no difference in onset times between drugs. The recovery time to TIITc 25 per cent following vecuronium (25.5 ± 6.3 min) was shorter than following atracurium (37.5 ± 7.0 min). Recovery times for d-tubocurarine and pancuronium were greater than sixty minutes. Elevation of heart rate occurred after administration of pancuronium (+29.8 per cent to +38.6 per cent) and dtubocurarine (+31 per cent to +34.9 per cent), but no change was observed after atracurium or vecuronium. Elevation of blood pressure was greatest following pancuronium (+10.8 to + 14.8 per cent). No significant change was observed following atracurium or vecuronium. A transient lowering of blood pressure (-9.3 per cent) occurred following d-tubocurarine.
Résumé
Afin de déterminer le début ďaction et le temp de récupération ainsi que les effets hémodynamiques des doses ďintubation ďatracurium (0.4 mg-kg-1), d-tubocurarine (0.8 mg-kg-1), pancuronium (0.12 mg-kg-1) et vécuronium 0.07 mg-kg-1), 67 enfants âgés de un à huit ans ont été étudiés sous anesthésie à ľhalothane et protoxyde ďazote. Le temps pris pour la dépression maximale du twitch et le temps de récupération de TIITc à 25 pour cent était enregistré avec un enregistreur EMG évoqué intégré. La fréquence cardiaque et la pression artérielle systolique étaient enregistrées pour cinq minutes après ľadministration du médicament et avant ľntubation. Il n’y avait aucune différence dans les temps du début ďaction entre les médicaments. Le temps de récupération de TIITc à 25 pour cent après vécuronium (25.5 ± 6.3 minutes) était plus court qu’après atracurium (37.5 ± 7.0 minutes). Les temps de récupération pour la d-tubocurarine et le pancuronium étaient supérieurs à 60 minutes. Ľaugmentation de la fréquence cardiaque est survenue après ľadministration de pancuronium (+29.8 à +38.6 pour cent) et d-tubocurarine (+31 à +34.9 pour cent), mais aucun changement n’a été observé après atracurium ou vécuronium. Ľélévation de la pression artérielle était supérieure après pancuronium (+10.8à +14.8 pour cent). Aucun changement significatif n’a été observé après atracurium ou vécuronium. Une diminution transitoire de la pression artérielle (-9.3 pour cent) est survenue après d-tubocurarine.
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Montgomery, C.J., Steward, D.J. A comparative evaluation of intubating doses of atracurium, d-tubocurarine, pancuronium and vecuronium in children. Can J Anaesth 35, 36–40 (1988). https://doi.org/10.1007/BF03010542
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DOI: https://doi.org/10.1007/BF03010542