Abstract
The purpose of the study was to evaluate the role of insulin in glucose kinetics after glucose administration using an insulinogenic index to indicate the magnitude of insulin response. The initial distribution volume of glucose (IDV-G) was calculated with a one-compartment model from repeated measurements of plasma glucose concentration three to seven minutes after administration of 100 mg · kg−1 glucose. The IDV-G was compared with the insulin response and the thermodilution assessments of cardiac output, measured simultaneously both before and after induced haemorrhage (30 ml · kg−1 over 30 min) in 12 adult mongrel dogs. The plasma insulin concentration was measured during the procedure and insulinogenic indices were calculated. There was no correlation between the IDV-G and insulinogenic indices, but there was a correlation between the IDV-G and thermodilution cardiac output before and after induced haemorrhage (r = 0.85, n = 24, P < 0.001). We conclude that the initial distribution volume of glucose is an indication of cardiac output in normo- and hypovolaemic dogs. Modification of glucose kinetics by the insulin response to glycaemic stimuli was negligible in that short period of time.
Résumé
Cette étude a pour objet l’évaluation, après l’administration de glucose, du rôle de l’insuline dans la cinétique du glucose en utilisant un index insulinogène précisant l’ordre de grandeur de la réponse insulinique. Le volume initial de distribution de glucose (VID-G) est calculé grâçe à un modèle à compartiment unique obtenu par des mesures répétées de la glycémie de trois à sept minutes après l’administration de 100 mg · kg−1 de glucose. Le VID-G est comparé à la réponse insulinique et au débit cardiaque par thermodilution, mesurés simultanément ayant et après une hémorragie provoquée (30 ml · kg−1 en 30 minutes) chez 12 chiens bâtards adultes. La concentration plasmatique de l’insuline est mesurée pendant le prélèvement et l’index insulinique calculé. Il n’existe pas de corrélation entre le VID-G et l’index insulinique, mais il en existe une entre le VID-G et le débit cardiaque avant et après l’hémorragie (r = 0,85, n = 24, P < 0,001). Nous concluons que le volume initial de distribution du glucose correspond au débit cardiaque chez le chien normo- et hypovolemique. Les modifications de la cinétique du glucose par la réponse insulinique au stimulus du glucose sont négligeables pendant cette courte période de temps.
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Shimodate, Y., Ishihara, H. & Matsuki, A. The initial distribution volume of glucose and cardiac output after haemorrhage in dogs. Can J Anaesth 41, 257–260 (1994). https://doi.org/10.1007/BF03009842
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DOI: https://doi.org/10.1007/BF03009842