Abstract
The effects of dobutamine (DOB) on diaphragmatic fatigue were examined in 20 anaesthetized, mechanically ventilated dogs. Animals were divided into two groups: the DOB group (n = 10) and the control group (n = 10). Diaphragmatic fatigue was induced by intermittent supramaximal electric stimulation applied to bilateral phrenic nerves at a frequency of 20 Hz for 30 min. Diaphragmatic contractility was assessed with transdiaphragmatic pressure (Pdi). After diaphragmatic fatigue, Pdi decreased at low-frequency (20 Hz) stimulation (P < 0.05), whereas the decrease was minimal at high-frequency (100 Hz) stimulation. In the DOB group, after producing fatigue, the continuous administration of 10 μg · kg−1 · min−1 dobutamine iv for 30 min produced an increased Pdi at both frequencies of stimulation (P < 0.05). The Pdi returned to pre-fatigue values after cessation of dobutamine administration. In the control group, the speed of recovery from fatigue was much slower at low-frequency stimulation. The integrated diaphragmatic electric activity (Edi) in the two groups did not change throughout the experiment at any frequency of stimulation. We conclude that dobutamine improves contractility in fatigued diaphragm.
Résumé
Cette étude porte sur les effets de la dobutamine (DOB) sur la fatigue diaphragmatique. Elle est réalisée sur 20 chiens anesthésiés et ventilés mécaniquement. Les animaux sont divisés en deux groupes: le groupe DOB (n = 10) et le groupe contrôle (n = 20). La fatigue diaphragmatique est initiée par stimulation électrique supramaximale appliquée aux deux nerfs phréniques à la fréquence de 20 Hz pendant 30 minutes. La contractilité diaphragmatique est évaluée par la mesure de la pression transdiaphragmatique (Pdi). Après l’obtention de la fatigue diaphramatique, la Pdi diminue à une fréquence basse (20 Hz) de simulation (P < 0,05). Par ailleurs, la diminution est négligeable à une stimulation de haute fréquence (100 Hz). Dans le groupe DOB, à l’état de fatigue, la perfusion continue de dobutamine 10 μg · kg−1 · min−1 iv pour 30 minutes produit une augmentation de la Pdi aux deux fréquences de stimulation (P < 0,05). La Pdi revient aux valeurs initiales après l’arrêt de la perfusion de dobutamine. Dans le groupe contrôle, la vitesse de récupération est beaucoup plus lente pour la simulation de basse fréquence. L’activité électrique diaphragmatique intégrée (Edi) ne change pas dans les deux groupes pendant l’expérimentation à chacune des fréquences de stimulation. Nous en concluons que la dobutamine améliore la contractilité du diaphragme fatigué.
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The study was supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan, #63480347.
This article has been retracted due to two reasons: Many variables reported in the studies are exceedingly unlikely. The author’s institution is not able to attest the integrity of the study and/or the data conducted under its auspices.
An erratum to this article can be found online at http://dx.doi.org/10.1007/s12630-012-9843-0.
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Fujii, Y., Toyooka, H., Ebata, T. et al. RETRACTED ARTICLE: Contractility of fatigued diaphragm is improved by dobutamine. Can J Anaesth 40, 453–458 (1993). https://doi.org/10.1007/BF03009517
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DOI: https://doi.org/10.1007/BF03009517