Abstract
A case of bleeding during operation due to propylthiouracil-induced thrombocytopenia is reported.
A 55 year old male who had been treated with Propylthiouracil for two months before operation underwent otherwise uneventful cervical laminectomy. Perioperatively he was transfused seven units of whole blood, two units of packed red cells, six units of platelets and two units of fresh frozen plasma for the estimated blood loss of 5500 ml. The patient underwent thyroidectomy without incident 45 days after withdrawal from Propylthiouracil.
The value of the preoperative coagulation studies of the patient treated with Propylthiouracil is discussed.
Résumé
Les auteurs rapportent un cas d’hémorragie per-opératoire causée par une thrombocytérmie déclenchée par le Propylthiouracil. Un homme de 55 ans traité depuis deux mois au Propylthiouracil a subis une laminectomie cervicale sans histoire à part le fait qu’il ait reçu sept unités de sang total, deux unités de culot globulaire, six unités de plaquettes et deux unités de plasma frais congelé pour une perte de sang évaluée à 5500 ml. Ce même malade subit une thyroïdectomie sans incident 45 jours après l’arrêt du Propylthiouracil. Les tests de coagulation obtenus chez ce malade traité au Propylthiouracil sont discutés.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Craddock, C.G, Shotton, D., Crockett, CI. &Leavell, B.S. Severe hypoprothrom- binemia following Propylthiouracil treatment of thyrotoxicosis. New Engl. J. Med.244: 549 (1951).
Gotta, A.W., Sullivan, C.A., Seamen, J. &Jean-Gilles, B. Prolonged intraoperative bleeding caused by propylthiouracil-induced hypo-prothrombinemia. Anesthesiology37: 562 (1972).
Weiss, H.J. Platelet physiology and abnormalities of platelet function. New Engl. J. Med.293: 580(1975).
Naeye, R.L. &Terrien, C.M. Hemorrhagic state after therapy with Propylthiouracil. Am. J. Clin. Path.34: 254 (1960).
Fewell, R.A., Engle, E.F. &Zimmerman, S.L. Acute thrombopenic purpura associated with administration of Propylthiouracil. JAMA143: 891 (1954).
Moore, F.D. Toxic manifestations of thiouracil therapy. JAMA130 315 (1946).
Martelo, O.J., Katims, R.B. &Yunis, A.A. Bone marrow aplasia following Propylthiouracil therapy. Arch. Intern. Med.120: 587 (1967).
Miller, R.D., Robbins, T.O., Tong, M.J. &Barton, S.L. Coagulation defects associated with massive blood transfusion. Ann. Surg.174:794(1971).
Miller, R.D. Complications of massive blood transfusion. Anesthesiology39: 82 (1973).
Bartels, E.G. Agranulocytosis during Propylthiouracil therapy. Am. J. Med.5: 48 (1948).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ikeda, S., Schweiss, J.F. Excessive blood loss during operation in the patient treated with propylthiouracil. Canad. Anaesth. Soc. J. 29, 477–480 (1982). https://doi.org/10.1007/BF03009412
Issue Date:
DOI: https://doi.org/10.1007/BF03009412